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Cell Signal Transduction Research Antibodies
p115 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight107895Da
Protein NameGeneral vesicular transport factor p115
Human Gene Id8615
Human Swiss Prot NoO60763
Mouse Swiss Prot NoQ9Z1Z0
Specificityp115 Polyclonal Antibody detects endogenous levels of p115 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameUSO1; VDP; General vesicular transport factor p115; Protein USO1 homolog; Transcytosis-associated protein; TAP; Vesicle-docking protein
Observed Band(KD)108
Functiondomain:Composed of a globular head, an elongated tail (coiled-coil) and a highly acidic C-terminal domain.,function:General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity.,PTM:Phosphorylated in a cell cycle-specific manner; phosphorylated in interphase but not in mitotic cells. Dephosphorylated protein associates with the Golgi membrane; phosphorylation promotes dissociation.,similarity:Belongs to the VDP/USO1/EDE1 family.,subcellular location:Recycles between the cytosol and the Golgi apparatus during interphase.,
Subcellular LocationCytoplasm, cytosol . Golgi apparatus membrane ; Peripheral membrane protein . Recycles between the cytosol and the Golgi apparatus during interphase. During interphase, the phosphorylated form is found exclusively in cytosol; the unphosphorylated form is associated with Golgi apparatus membranes. .
ExpressionEpithelium,Human skeletal muscle,Liver,Uterus,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human USO1. AA range:913-962
Gene NameUSO1
DilutionWestern Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
BackgroundUSO1 vesicle transport factor(USO1) Homo sapiens The protein encoded by this gene is a peripheral membrane protein which recycles between the cytosol and the Golgi apparatus during interphase. It is regulated by phosphorylation: dephosphorylated protein associates with the Golgi membrane and dissociates from the membrane upon phosphorylation. Ras-associated protein 1 recruits this protein to coat protein complex II (COPII) vesicles during budding from the endoplasmic reticulum, where it interacts with a set of COPII vesicle-associated SNAREs to form a cis-SNARE complex that promotes targeting to the Golgi apparatus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014],
Conjugated Antibody
This product is also available conjugated. Format: E20-73485-Conjugate. Price: $485 / Size: 100μl.
E20-73485-FITC$485 / 100μlE20-73485-Biotin$485 / 100μlE20-73485-HRP$485 / 100μlE20-73485-AP$485 / 100μlE20-73485-AF350$485 / 100μlE20-73485-AF405M$485 / 100μlE20-73485-AF488$485 / 100μlE20-73485-AF514$485 / 100μlE20-73485-AF532$485 / 100μlE20-73485-AF555$485 / 100μlE20-73485-AF568$485 / 100μlE20-73485-AF405S$485 / 100μlE20-73485-AF405L$485 / 100μlE20-73485-AF546$485 / 100μlE20-73485-AF594$485 / 100μlE20-73485-AF610$485 / 100μlE20-73485-AF635$485 / 100μlE20-73485-AF647$485 / 100μlE20-73485-AF680$485 / 100μlE20-73485-AF700$485 / 100μlE20-73485-AF750$485 / 100μlE20-73485-AF790$485 / 100μlE20-73485-APC$485 / 100μlE20-73485-PE$485 / 100μlE20-73485-Cy3$485 / 100μlE20-73485-Cy5$485 / 100μlE20-73485-Cy5.5$485 / 100μlE20-73485-Cy7$485 / 100μlE20-73485-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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