Product Information
Molecular Weight38322Da
Protein NameUbiquitin thioesterase OTU1
Human Gene Id55432
Human Swiss Prot NoQ5VVQ6
Mouse Swiss Prot NoQ8CB27
SpecificityOTUD2 Polyclonal Antibody detects endogenous levels of OTUD2 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameYOD1; DUBA8; HIN7; OTUD2; Ubiquitin thioesterase OTU1; DUBA-8; HIV-1-induced protease 7; HIN-7; HsHIN7; OTU domain-containing protein 2
Observed Band(KD)35
Functionfunction:Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation.,sequence caution:Wrong choice of frame.,similarity:Contains 1 C2H2-type zinc finger.,similarity:Contains 1 OTU domain.,
Subcellular LocationCytoplasm . Recruited to damaged lysosomes decorated with K48-linked ubiquitin chains. .
ExpressionFetal liver,Spinal cord,Testis,
BackgroundYOD1 deubiquitinase(YOD1) Homo sapiens Protein ubiquitination controls many intracellular processes, including cell cycle progression, transcriptional activation, and signal transduction. This dynamic process, involving ubiquitin conjugating enzymes and deubiquitinating enzymes, adds and removes ubiquitin. Deubiquitinating enzymes are cysteine proteases that specifically cleave ubiquitin from ubiquitin-conjugated protein substrates. The protein encoded by this gene belongs to a DUB subfamily characterized by an ovarian tumor (OTU) domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013],