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Cell Signal Transduction Research Antibodies
OPG Polyclonal Antibody
Human;Mouse
WB;IF/ICC;ELISA
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight46040DaObserved Band:55KD
Protein NameTumor necrosis factor receptor superfamily member 11B
Human Gene Id4982
Human Swiss Prot NoO00300
Mouse Gene Id18383
Mouse Swiss Prot NoO08712
SpecificityOPG Polyclonal Antibody detects endogenous levels of OPG protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameTNFRSF11B; OCIF; OPG; Tumor necrosis factor receptor superfamily member 11B; Osteoclastogenesis inhibitory factor; Osteoprotegerin
Functiondisease:Defects in TNFRSF11B are the cause of juvenile Paget disease (JPD) [MIM:239000]; also called hyperostosis corticalis deformans juvenilis or hereditary hyperphosphatasia or chronic congenital idiopathic hyperphosphatasia. JPD is a rare autosomal recessive osteopathy that presents in infancy or early childhood. The disorder is characterized by rapidly remodeling woven bone, osteopenia, debilitating fractures, and deformities due to a markedly accelerated rate of bone remodeling throughout the skeleton. Approximately 40 cases of JPD have been reported worldwide. Unless it is treated with drugs that block osteoclast-mediated skeletal resorption, the disease can be fatal.,function:Acts as decoy receptor for RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depen
Subcellular LocationSecreted.
ExpressionHighly expressed in adult lung, heart, kidney, liver, spleen, thymus, prostate, ovary, small intestine, thyroid, lymph node, trachea, adrenal gland, testis, and bone marrow. Detected at very low levels in brain, placenta and skeletal muscle. Highly expressed in fetal kidney, liver and lung.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human TR11B . AA range:10-59
Gene NameTNFRSF11B
DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000. IF 1:100-300 Not yet tested in other applications.
BackgroundTNF receptor superfamily member 11b(TNFRSF11B) Homo sapiens The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. [provided by RefSeq, Jul 2008],
Conjugated Antibody
This product is also available conjugated. Format: E20-73466-Conjugate. Price: $485 / Size: 100μl.
E20-73466-FITC$485 / 100μlE20-73466-Biotin$485 / 100μlE20-73466-HRP$485 / 100μlE20-73466-AP$485 / 100μlE20-73466-AF350$485 / 100μlE20-73466-AF405M$485 / 100μlE20-73466-AF488$485 / 100μlE20-73466-AF514$485 / 100μlE20-73466-AF532$485 / 100μlE20-73466-AF555$485 / 100μlE20-73466-AF568$485 / 100μlE20-73466-AF405S$485 / 100μlE20-73466-AF405L$485 / 100μlE20-73466-AF546$485 / 100μlE20-73466-AF594$485 / 100μlE20-73466-AF610$485 / 100μlE20-73466-AF635$485 / 100μlE20-73466-AF647$485 / 100μlE20-73466-AF680$485 / 100μlE20-73466-AF700$485 / 100μlE20-73466-AF750$485 / 100μlE20-73466-AF790$485 / 100μlE20-73466-APC$485 / 100μlE20-73466-PE$485 / 100μlE20-73466-Cy3$485 / 100μlE20-73466-Cy5$485 / 100μlE20-73466-Cy5.5$485 / 100μlE20-73466-Cy7$485 / 100μlE20-73466-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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