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Cell Signal Transduction Research Antibodies
Op18 Polyclonal Antibody
Human;Rat;Mouse
WB;IF/ICC;ELISA
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight17303DaObserved Band:17KD
Protein NameStathmin
Human Gene Id3925
Human Swiss Prot NoP16949
Mouse Gene Id16765
Mouse Swiss Prot NoP54227
Rat Gene Id29332
Rat Swiss Prot NoP13668
SpecificityOp18 Polyclonal Antibody detects endogenous levels of Op18 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameSTMN1; C1orf215; LAP18; OP18; Stathmin; Leukemia-associated phosphoprotein p18; Metablastin; Oncoprotein 18; Op18; Phosphoprotein p19; pp19; Prosolin; Protein Pr22; pp17
Functiondisease:Present in much greater abundance in cells from patients with acute leukemia of different subtypes than in normal peripheral blood lymphocytes, non-leukemic proliferating lymphoid cells, bone marrow cells, or cells from patients with chronic lymphoid or myeloid leukemia.,function:Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear.,PTM:Many different phosphorylated forms are observed depending on specific combinations among the sites which can be phosphorylated. MAPK is responsible for the phosphorylation of stathmin in response to NGF. Phosphorylation at Ser-16 seems to be required for neuron polarization (By similarity). Phosphorylation at
Subcellular LocationCytoplasm, cytoskeleton.
ExpressionUbiquitous. Expression is strongest in fetal and adult brain, spinal cord, and cerebellum, followed by thymus, bone marrow, testis, and fetal liver. Expression is intermediate in colon, ovary, placenta, uterus, and trachea, and is readily detected at substantially lower levels in all other tissues examined. Lowest expression is found in adult liver. Present in much greater abundance in cells from patients with acute leukemia of different subtypes than in normal peripheral blood lymphocytes, non-leukemic proliferating lymphoid cells, bone marrow cells, or cells from patients with chronic lymphoid or myeloid leukemia.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human Stathmin 1. AA range:5-54
Gene NameSTMN1
DilutionWestern Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Backgroundstathmin 1(STMN1) Homo sapiens This gene belongs to the stathmin family of genes. It encodes a ubiquitous cytosolic phosphoprotein proposed to function as an intracellular relay integrating regulatory signals of the cellular environment. The encoded protein is involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009],
Conjugated Antibody
This product is also available conjugated. Format: E20-73465-Conjugate. Price: $485 / Size: 100μl.
E20-73465-FITC$485 / 100μlE20-73465-Biotin$485 / 100μlE20-73465-HRP$485 / 100μlE20-73465-AP$485 / 100μlE20-73465-AF350$485 / 100μlE20-73465-AF405M$485 / 100μlE20-73465-AF488$485 / 100μlE20-73465-AF514$485 / 100μlE20-73465-AF532$485 / 100μlE20-73465-AF555$485 / 100μlE20-73465-AF568$485 / 100μlE20-73465-AF405S$485 / 100μlE20-73465-AF405L$485 / 100μlE20-73465-AF546$485 / 100μlE20-73465-AF594$485 / 100μlE20-73465-AF610$485 / 100μlE20-73465-AF635$485 / 100μlE20-73465-AF647$485 / 100μlE20-73465-AF680$485 / 100μlE20-73465-AF700$485 / 100μlE20-73465-AF750$485 / 100μlE20-73465-AF790$485 / 100μlE20-73465-APC$485 / 100μlE20-73465-PE$485 / 100μlE20-73465-Cy3$485 / 100μlE20-73465-Cy5$485 / 100μlE20-73465-Cy5.5$485 / 100μlE20-73465-Cy7$485 / 100μlE20-73465-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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