Product Information
Molecular Weight87965Da
Protein NameCadherin-11
Human Gene Id1009
Human Swiss Prot NoP55287
Mouse Gene Id12552
Mouse Swiss Prot NoP55288
SpecificityOB-cadherin Polyclonal Antibody detects endogenous levels of OB-cadherin protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameCDH11; Cadherin-11; OSF-4; Osteoblast cadherin; OB-cadherin
Observed Band(KD)85
Functionfunction:Cadherins are calcium dependent cell adhesion proteins.,function:Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.,similarity:Contains 5 cadherin domains.,tissue specificity:Expressed mainly in brain but also found in other tissues. Expressed in neuroblasts.,
Subcellular LocationCell membrane; Single-pass type I membrane protein.
ExpressionExpressed mainly in brain but also found in other tissues. Expressed in neuroblasts.
BackgroundThis gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Expression of this particular cadherin in osteoblastic cell lines, and its upregulation during differentiation, suggests a specific function in bone development and maintenance. [provided by RefSeq, Jul 2008],