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Ob Polyclonal Antibody
Datasheet
Catalog Number:
E20-73223Amount:
100ulApplications:
IHC-p;IF(paraffin section);ELISAReactivity:
Human;Mouse;RatPurification:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.Immunogen:
The antiserum was produced against synthesized peptide derived from human Ob. AA range:36-85Source:
Polyclonal, RabbitGene Name:
LEPDilution:
Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.
- Immunohistochemistry analysis of Ob antibody in paraffin-embedded human breast carcinoma tissue.
Background:
leptin(LEP) Homo sapiens This gene encodes a protein that is secreted by white adipocytes, and which plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions cause severe obesity, and morbid obesity with hypogonadism. This gene has also been linked to type 2 diabetes mellitus development. [provided by RefSeq, Jul 2008],Protein Name:
LeptinHuman Gene Id:
3952Human Swiss Prot No:
P41159Mouse Gene Id:
16846Mouse Swiss Prot No:
P41160Rat Gene Id:
25608Rat Swiss Prot No:
P50596Specificity:
Ob Polyclonal Antibody detects endogenous levels of Ob protein.Formulation:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.Concentration:
1 mg/mlStorage Stability:
-20°C/1 yearOther Name:
LEP; OB; OBS; Leptin; Obese protein; Obesity factorMolecularWeight(Da):
18641Function:
disease:Defects in LEP may be a cause of autosomal recessive obesity [MIM:601665].,function:May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass.,online information:Leptin entry,similarity:Belongs to the leptin family.,subunit:Interacts with SIGLEC6.,Subcellular Location:
extracellular region,extracellular space,cytoplasm,Expression:
PCR rescued clones,Placenta,
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