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NuMA Polyclonal Antibody
Datasheet
Catalog Number:
E20-73210Amount:
100ulPrice:
225$Purification:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.Immunogen:
The antiserum was produced against synthesized peptide derived from human NUMA1. AA range:334-383Source:
Polyclonal, Rabbit
- Western Blot analysis of A549 cells using NuMA Polyclonal Antibody diluted at 1:2000
Gene Name:
NUMA1Dilution:
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.Background:
nuclear mitotic apparatus protein 1(NUMA1) Homo sapiens This gene encodes a large protein that forms a structural component of the nuclear matrix. The encoded protein interacts with microtubules and plays a role in the formation and organization of the mitotic spindle during cell division. Chromosomal translocation of this gene with the RARA (retinoic acid receptor, alpha) gene on chromosome 17 have been detected in patients with acute promyelocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013],Protein Name:
Nuclear mitotic apparatus protein 1Human Gene Id:
4926Human Swiss Prot No:
Q14980Specificity:
NuMA Polyclonal Antibody detects endogenous levels of NuMA protein.Formulation:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.Concentration:
1 mg/mlStorage Stability:
-20°C/1 yearOther Name:
NUMA1; NUMA; Nuclear mitotic apparatus protein 1; NuMA protein; SP-H antigenMolecularWeight(Da):
238260Observed Band(KD):
240Function:
function:May be a structural component of the nucleus.,subcellular location:Dissociates from condensing chromosomes during early prophase, before the complete disintegration of the nuclear lamina. As mitosis progresses it reassociates with telophase chromosomes very early during nuclear reformation, before substantial accumulation of lamins on chromosomal surfaces is evident.,Subcellular Location:
Golgi membrane,spindle pole,nucleus,nucleoplasm,chromosome,cytoplasm,centrosome,spindle,cytosol,spindle microtubule,cell cortex,nuclear matrix,dendrite,neuronal cell body,apical pExpression:
Brain,Epithelium,Kidney,Lung,Muscle,Ovary,Testis,Uterus
- Western blot analysis of NUMA1 Antibody. The lane on the right is blocked with the NUMA1 peptide.
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