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NTR1 Polyclonal Antibody
Datasheet
Catalog Number:
E20-73203Amount:
100ulPrice:
225$Purification:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.Immunogen:
Synthesized peptide derived from part region of human proteinSource:
Polyclonal, RabbitGene Name:
ANTXR1 ATR TEM8Dilution:
WB 1:500-2000 ELISA 1:5000-20000Background:
anthrax toxin receptor 1(ANTXR1) Homo sapiens This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described. [provided by RefSeq, Oct 2008],Protein Name:
Anthrax toxin receptor 1 (Tumor endothelial marker 8)Human Gene Id:
84168Human Swiss Prot No:
Q9H6X2Mouse Swiss Prot No:
Q9CZ52Rat Swiss Prot No:
Q0PMD2Specificity:
ANTR1 Polyclonal Antibody detects endogenous levels of protein.Formulation:
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.Concentration:
1 mg/mlStorage Stability:
-20°C/1 yearObserved Band(KD):
62Function:
alternative products:Experimental confirmation may be lacking for some isoforms,domain:Binding to PA seems to be effected through the VWA domain.,function:Cellular role is not yet known.,similarity:Belongs to the ATR family.,similarity:Contains 1 VWFA domain.,subunit:Binds to the protective antigen (PA) of Bacillus anthracis. Binding does not occur in the presence of calcium.,tissue specificity:Highly expressed in tumor endothelial cells but not in normal endothelial cells.,Subcellular Location:
plasma membrane,external side of plasma membrane,cell surface,endosome membrane,integral component of membrane,lamellipodium membrane,filopodium membrane,extracellular exosome,Expression:
Breast,Epithelium,Kidney,Placenta,Stomach mucosa,
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