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NM23-H2 Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-73147

  • Amount:

    100ul

  • Price:

    225$

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human NM23. AA range:91-140

  • Source:

    Polyclonal, Rabbit

  • Gene Name:

    NME2

  • Dilution:

    Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications.

  • Western blot analysis of lysates from K562 cells, using NM23 Antibody. The lane on the right is blocked with the synthesized peptide.

  • Background:

    NME/NM23 nucleoside diphosphate kinase 2(NME2) Homo sapiens Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by NME1) and 'B' (encoded by this gene) isoforms. Multiple alternatively spliced transcript variants have been found for this gene. Read-through transcription from the neighboring upstream gene (NME1) generates naturally-occurring transcripts (NME1-NME2) that encode a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Nov 2010],

  • Protein Name:

    Nucleoside diphosphate kinase B

  • Human Gene Id:

    4831/654364

  • Human Swiss Prot No:

    P22392

  • Mouse Gene Id:

    18103

  • Mouse Swiss Prot No:

    Q01768

  • Rat Gene Id:

    83782

  • Rat Swiss Prot No:

    P19804

  • Specificity:

    NM23-H2 Polyclonal Antibody detects endogenous levels of NM23-H2 protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    NME2; NM23B; Nucleoside diphosphate kinase B; NDK B; NDP kinase B; C-myc purine-binding transcription factor PUF; Histidine protein kinase NDKB; nm23-H2

  • MolecularWeight(Da):

    17298

  • Observed Band(KD):

    23

  • Function:

    catalytic activity:ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.,cofactor:Magnesium.,disease:This protein is found in reduced amount in tumor cells of high metastatic potential.,disease:This protein is found in reduced amount in tumor cells of high metastatic potential. Somatic mutations of NME1 are found in neuroblastoma. Increased NME1 in neuroblastoma is correlated with features of the disease that are associated with aggressive tumors. May therefore have distinct if not opposite roles in different tumors.,enzyme regulation:Autophosphorylation at His-118 increases serine/threonine protein kinase activity of the enzyme. Interaction with the SET complex inhibits exonuclease activity.,function:Major role in the synthesis of nucleoside triphosphates other than ATP. Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the

  • Subcellular Location:

    ruffle,nucleus,cytoplasm,cytosol,intermediate filament,focal adhesion,lamellipodium,mitochondrial membrane,myelin sheath,perinuclear region of cytoplasm,extracellular exosome,cell periphery,

  • Expression:

    Brain,Cajal-Retzius cell,Chondrosarcoma,Eye,Fetal brain cortex,Lung

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Catalog Number

  • Amount:100ul
  • Price:225$

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NM23-H2 Polyclonal Antibody | EnoGene Biotech Co. Ltd