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Nibrin Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-73121

  • Amount:

    100ul

  • Molecular Weight:

    84959Da

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human Nibrin. AA range:251-300

  • Source:

    Polyclonal, Rabbit

  • Gene Name:

    NBN

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.

  • Immunofluorescence analysis of A549 cells, using Nibrin Antibody. The picture on the right is blocked with the synthesized peptide.

  • Background:

    nibrin(NBN) Homo sapiens Mutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation. [provided by RefSeq, Jul 2008],

  • Protein Name:

    Nibrin

  • Human Gene Id:

    4683

  • Human Swiss Prot No:

    O60934

  • Mouse Swiss Prot No:

    Q9R207

  • Specificity:

    Nibrin Polyclonal Antibody detects endogenous levels of Nibrin protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    NBN; NBS; NBS1; P95; Nibrin; Cell cycle regulatory protein p95; Nijmegen breakage syndrome protein 1

  • Observed Band(KD):

    85

  • Function:

    disease:Defects in NBN are a cause of genetic susceptibility to breast cancer (BC) [MIM:114480]. BC is an extremely common malignancy, affecting one in eight women during their lifetime. A positive family history has been identified as major contributor to risk of development of the disease, and this link is striking for early-onset breast cancer.,disease:Defects in NBN are the cause of Nijmegen breakage syndrome (NBS) [MIM:251260]. NBS is an autosomal recessive syndrome characterized by chromosomal instability, radiation sensitivity, microcephaly, growth retardation, immunodeficiency and predisposition to cancer, particularly to lymphoid malignancies.,disease:Defects in NBN may be associated with aplastic anemia [MIM:609135]. Aplastic anemia is a disease of bone-marrow failure characterized by peripheral pancytopenia and marrow hypoplasia. Most of the cases of aplastic anemia are idiopa

  • Subcellular Location:

    chromosome, telomeric region,nuclear chromosome, telomeric region,nucleus,nucleoplasm,replication fork,nucleolus,cytosol,PML body,Mre11 complex,site of double-strand break,nuclear inclusion body,

  • Expression:

    Brain,Colon endothelium,Epithelium,Fibroblast,Skin,Synovial cell,

  • Western blot analysis of lysates from Jurkat cells, using Nibrin Antibody. The lane on the right is blocked with the synthesized peptide.

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Catalog Number

  • Amount:100ul
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Nibrin Polyclonal Antibody | EnoGene Biotech Co. Ltd