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NGFR p75 Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-73116

  • Amount:

    100ul

  • Molecular Weight:

    45183Da

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human NGFR p75. AA range:230-279

  • Source:

    Polyclonal, Rabbit

  • Western Blot analysis of various cells using NGFR p75 Polyclonal Antibody diluted at 1:2000

  • Gene Name:

    NGFR

  • Dilution:

    Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.

  • Protein Name:

    Tumor necrosis factor receptor superfamily member 16

  • Human Gene Id:

    4804

  • Human Swiss Prot No:

    P08138

  • Mouse Swiss Prot No:

    Q9Z0W1

  • Rat Gene Id:

    24596

  • Rat Swiss Prot No:

    P07174

  • Specificity:

    NGFR p75 Polyclonal Antibody detects endogenous levels of NGFR p75 protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    NGFR; TNFRSF16; Tumor necrosis factor receptor superfamily member 16; Gp80-LNGFR; Low affinity neurotrophin receptor p75NTR; Low-affinity nerve growth factor receptor; NGF receptor; p75 ICD; CD antigen CD271

  • Observed Band(KD):

    75

  • Background:

    nerve growth factor receptor(NGFR) Homo sapiens Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. [provided by RefSeq, Jul 2008],

  • Function:

    domain:Death domain is responsible for interaction with RANBP9.,domain:The extracellular domain is responsible for interaction with NTRK1.,function:Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells.,PTM:N- and O-glycosylated.,PTM:O-linked glycans consist of Gal(1-3)GalNAc core elongated by 1 or 2 NeuNAc.,PTM:Phosphorylated on serine residues.,similarity:Contains 1 death domain.,similarity:Contains 4 TNFR-Cys repeats.,subunit:Homodimer; disulfide-linked. Interacts with p75NTR-associated cell death executor. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with BEX1 and NGFRAP1/BEX3. Interacts with KIDINS220 and NTRK1. Can form a ternary complex with NTRK1 and KIDINS220 and this complex is affected by the expression levels of KIDI

  • Subcellular Location:

    Cell membrane ; Single-pass type I membrane protein . Perikaryon . Cell projection, growth cone . Cell projection, dendritic spine .

  • Expression:

    Brain,

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Catalog Number

  • Amount:100ul
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NGFR p75 Polyclonal Antibody | EnoGene Biotech Co. Ltd