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Neuro D Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-73061

  • Amount:

    100ul

  • Price:

    225$

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human NEUROD1. AA range:240-289

  • Source:

    Polyclonal, Rabbit

  • Gene Name:

    NEUROD1

  • Dilution:

    Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications.

  • Western blot analysis of lysates from HeLa cells, using Neuro D Antibody. The lane on the right is blocked with the synthesized peptide.

  • Background:

    neuronal differentiation 1(NEUROD1) Homo sapiens This gene encodes a member of the NeuroD family of basic helix-loop-helix (bHLH) transcription factors. The protein forms heterodimers with other bHLH proteins and activates transcription of genes that contain a specific DNA sequence known as the E-box. It regulates expression of the insulin gene, and mutations in this gene result in type II diabetes mellitus. [provided by RefSeq, Jul 2008],

  • Protein Name:

    Neurogenic differentiation factor 1

  • Human Gene Id:

    4760

  • Human Swiss Prot No:

    Q13562

  • Mouse Gene Id:

    18012

  • Mouse Swiss Prot No:

    Q60867

  • Rat Gene Id:

    29458

  • Rat Swiss Prot No:

    Q64289

  • Specificity:

    Neuro D Polyclonal Antibody detects endogenous levels of Neuro D protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    NEUROD1; BHLHA3; NEUROD; Neurogenic differentiation factor 1; NeuroD; NeuroD1; Class A basic helix-loop-helix protein 3; bHLHa3

  • MolecularWeight(Da):

    39890

  • Observed Band(KD):

    36

  • Function:

    disease:Defects in NEUROD1 are the cause of maturity onset diabetes of the young type 6 (MODY6) [MIM:606394]. MODY [MIM:606391] is characterized by an autosomal dominant mode of inheritance, onset during young adulthood and a primary defect in insulin secretion.,function:Differentiation factor required for dendrite morphogenesis and maintenance in the cerebellar cortex. Transcriptional activator. Binds to the insulin gene E-box.,PTM:Phosphorylated. In islet cells, phosphorylated on Ser-274 upon glucose stimulation; which may be required for nuclear localization. In activated neurons, phosphorylated on Ser-335; which promotes dendritic growth.,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,subunit:Efficient DNA binding requires dimerization with another bHLH protein. Heterodimer with TCF3/E47. Interacts with RREB1.,

  • Subcellular Location:

    nucleus,nucleoplasm,cytoplasm,RNA polymerase II transcription factor complex,

  • Expression:

    Eye,Retina,Rhabdomyosarcoma,

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Catalog Number

  • Amount:100ul
  • Price:225$

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Neuro D Polyclonal Antibody | EnoGene Biotech Co. Ltd