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Netrin-1 Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-73042

  • Amount:

    100ul

  • Molecular Weight:

    67734Da

  • Applications:

    WB;IHC-p;IF(paraffin section);ELISA

  • Reactivity:

    Human;Mouse;Rat;Monkey

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human Netrin-1. AA range:484-533

  • Source:

    Polyclonal, Rabbit

  • Western Blot analysis of COS7 cells using Netrin-1 Polyclonal Antibody diluted at 1:1000

  • Gene Name:

    NTN1

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.

  • Protein Name:

    Netrin-1

  • Human Gene Id:

    9423

  • Human Swiss Prot No:

    O95631

  • Mouse Gene Id:

    18208

  • Mouse Swiss Prot No:

    O09118

  • Rat Gene Id:

    114523

  • Rat Swiss Prot No:

    Q924Z9

  • Specificity:

    Netrin-1 Polyclonal Antibody detects endogenous levels of Netrin-1 protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    NTN1; NTN1L; Netrin-1; Epididymis tissue protein Li 131P

  • Observed Band(KD):

    75

  • Background:

    netrin 1(NTN1) Homo sapiens Netrin is included in a family of laminin-related secreted proteins. The function of this gene has not yet been defined; however, netrin is thought to be involved in axon guidance and cell migration during development. Mutations and loss of expression of netrin suggest that variation in netrin may be involved in cancer development. [provided by RefSeq, Jul 2008],

  • Function:

    disease:Defects in NTN1 are associated with some forms of neuroblastomas.,function:Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in colorectal tumorigenesis by regulating apoptosis.,similarity:Contains 1 laminin N-terminal domain.,similarity:Contains 1 NTR domain.,similarity:Contains 3 laminin EGF-like domains.,subunit:Binds to its receptors; DCC, UNC5A, UNC5B, UNC5C and probably UNC5D.,tissue specificity:Widely expressed in normal adult tissues with highest levels in heart, small intestine, colon, liver and prostate. Reduced expression in brain tumors and neuroblastomas.,

  • Subcellular Location:

    Secreted . Cytoplasm . Mainly secreted. .

  • Expression:

    Widely expressed in normal adult tissues with highest levels in heart, small intestine, colon, liver and prostate. Reduced expression in brain tumors and neuroblastomas. Expressed in epididymis (at protein level).

  • Immunohistochemistry analysis of Netrin-1 antibody in paraffin-embedded human lung carcinoma tissue.

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