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Nephrin Polyclonal Antibody
Datasheet
Catalog Number:
E20-73036Amount:
100ulPrice:
225$Purification:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.Immunogen:
The antiserum was produced against synthesized peptide derived from human Nephrin. AA range:843-892Source:
Polyclonal, RabbitGene Name:
NPHS1Dilution:
Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.
- Immunohistochemistry analysis of Nephrin antibody in paraffin-embedded human brain tissue.
Background:
NPHS1, nephrin(NPHS1) Homo sapiens This gene encodes a member of the immunoglobulin family of cell adhesion molecules that functions in the glomerular filtration barrier in the kidney. The gene is primarily expressed in renal tissues, and the protein is a type-1 transmembrane protein found at the slit diaphragm of glomerular podocytes. The slit diaphragm is thought to function as an ultrafilter to exclude albumin and other plasma macromolecules in the formation of urine. Mutations in this gene result in Finnish-type congenital nephrosis 1, characterized by severe proteinuria and loss of the slit diaphragm and foot processes.[provided by RefSeq, Oct 2009],Protein Name:
NephrinHuman Gene Id:
4868Human Swiss Prot No:
O60500Mouse Gene Id:
54631Mouse Swiss Prot No:
Q9QZS7Rat Gene Id:
64563Rat Swiss Prot No:
Q9R044Specificity:
Nephrin Polyclonal Antibody detects endogenous levels of Nephrin protein.Formulation:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.Concentration:
1 mg/mlStorage Stability:
-20°C/1 yearOther Name:
NPHS1; NPHN; Nephrin; Renal glomerulus-specific cell adhesion receptorMolecularWeight(Da):
134742Function:
developmental stage:In 23-week-old embryo found in epithelial podocytes of the periphery of mature and developing glomeruli.,disease:Defects in NPHS1 are the cause of congenital nephrotic syndrome of the Finnish type (NPHS1 or CNF) [MIM:256300]. CNF is an autosomal recessive disorder characterized by massive proteinuria in utero and nephrosis at birth.,function:Seems to play a role in the development or function of the kidney glomerular filtration barrier. May anchor the podocyte slit diaphragm to the actin cytoskeleton.,PTM:Phosphorylated on tyrosine residues.,similarity:Belongs to the immunoglobulin superfamily.,similarity:Contains 1 fibronectin type-III domain.,similarity:Contains 8 Ig-like C2-type (immunoglobulin-like) domains.,subcellular location:Predominantly located at podocyte slit diaphragm between podocyte foot processes. Also associated with podocyte apical plasma membrane.,sSubcellular Location:
intracellular,plasma membrane,integral component of plasma membrane,slit diaphragm,cell projection,extracellular exosome,Expression:
Platelet,
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Catalog Number
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