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NBK Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-72983

  • Amount:

    100ul

  • Molecular Weight:

    18016Da

  • Applications:

    WB;IHC-p;IF/ICC;ELISA

  • Reactivity:

    Human;Rat;Mouse;

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human BIK. AA range:18-67

  • Source:

    Polyclonal, Rabbit

  • Western Blot analysis of various cells using NBK Polyclonal Antibody diluted at 1:500

  • Gene Name:

    BIK

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.

  • Protein Name:

    Bcl-2-interacting killer

  • Human Gene Id:

    638

  • Human Swiss Prot No:

    Q13323

  • Mouse Swiss Prot No:

    O70337

  • Specificity:

    NBK Polyclonal Antibody detects endogenous levels of NBK protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    BIK; NBK; Bcl-2-interacting killer; Apoptosis inducer NBK; BIP1; BP4

  • Observed Band(KD):

    30 25

  • Background:

    BCL2 interacting killer(BIK) Homo sapiens The protein encoded by this gene shares a critical BH3 domain with other death-promoting proteins, such as BID, BAK, BAD and BAX, that is required for its pro-apoptotic activity, and for interaction with anti-apoptotic members of the BCL2 family, and viral survival-promoting proteins. Since the activity of this protein is suppressed in the presence of survival-promoting proteins, it is suggested as a likely target for anti-apoptotic proteins. [provided by RefSeq, Sep 2011],

  • Function:

    domain:Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.,function:Accelerates programmed cell death. Binding to the apoptosis repressors Bcl-X(L), BHRF1, Bcl-2 or its adenovirus homolog E1B 19k protein suppresses this death-promoting activity. Does not interact with BAX.,subcellular location:Around the nuclear envelope, and in cytoplasmic membranes.,

  • Subcellular Location:

    Endomembrane system; Single-pass membrane protein. Mitochondrion membrane ; Single-pass membrane protein . Around the nuclear envelope, and in cytoplasmic membranes.

  • Expression:

    B-cell,Lymph,Lymphoid,

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Catalog Number

  • Amount:100ul
  • Price:225$

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NBK Polyclonal Antibody | EnoGene Biotech Co. Ltd