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Na+ CP type IIβ Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-72965

  • Amount:

    100ul

  • Molecular Weight:

    24326Da

  • Applications:

    WB;ELISA;IHC-p

  • Reactivity:

    Human;Mouse;Rat

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human SCN2B. AA range:71-120

  • Source:

    Polyclonal, Rabbit

  • Western Blot analysis of various cells using Na+ CP type IIβ Polyclonal Antibody

  • Gene Name:

    SCN2B

  • Dilution:

    WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000

  • Protein Name:

    Sodium channel subunit beta-2

  • Human Gene Id:

    6327

  • Human Swiss Prot No:

    O60939

  • Mouse Gene Id:

    72821

  • Mouse Swiss Prot No:

    Q56A07

  • Rat Gene Id:

    25349

  • Rat Swiss Prot No:

    P54900

  • Specificity:

    Na+ CP type IIβ Polyclonal Antibody detects endogenous levels of Na+ CP type IIβ protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    SCN2B; Sodium channel subunit beta-2

  • Observed Band(KD):

    24

  • Background:

    sodium voltage-gated channel beta subunit 2(SCN2B) Homo sapiens The protein encoded by this gene is the beta 2 subunit of the type II voltage-gated sodium channel. The encoded protein is involved in cell-cell adhesion and cell migration. Defects in this gene can be a cause of Brugada Syndrome, atrial fibrillation, or sudden infant death syndrome. [provided by RefSeq, Jul 2015],

  • Function:

    function:Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli. Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier.,similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,subunit:The sodium channel consists of a pore-forming alpha subunit, beta-1 and beta-2 subunits. Beta-1 is non-covalently associated with alpha, while beta-2 is covalently linked by disulfide bonds. Interaction with SCN10A and TNR.,tissue specificity:Brain specific.,

  • Subcellular Location:

    Membrane; Single-pass type I membrane protein.

  • Expression:

    Brain specific.

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Catalog Number

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