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Myt 1 Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-72958

  • Amount:

    100ul

  • Molecular Weight:

    54521Da

  • Applications:

    WB;IHC-p;IF(paraffin section);ELISA

  • Reactivity:

    Human;Rat;Mouse;

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human PKMYT1. AA range:49-98

  • Source:

    Polyclonal, Rabbit

  • Western Blot analysis of various cells using Myt 1 Polyclonal Antibody diluted at 1:2000

  • Gene Name:

    PKMYT1

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.

  • Protein Name:

    Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase

  • Human Gene Id:

    9088

  • Human Swiss Prot No:

    Q99640

  • Mouse Swiss Prot No:

    Q9ESG9

  • Specificity:

    Myt 1 Polyclonal Antibody detects endogenous levels of Myt 1 protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    PKMYT1; MYT1; Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase; Myt1 kinase

  • Observed Band(KD):

    50

  • Background:

    protein kinase, membrane associated tyrosine/threonine 1(PKMYT1) Homo sapiens This gene encodes a member of the serine/threonine protein kinase family. The encoded protein is a membrane-associated kinase that negatively regulates the G2/M transition of the cell cycle by phosphorylating and inactivating cyclin-dependent kinase 1. The activity of the encoded protein is regulated by polo-like kinase 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012],

  • Function:

    catalytic activity:ATP + a protein = ADP + a phosphoprotein.,domain:The membrane-association motif is essential for the localization to membrane of Golgi stack. According to some authors, it is a transmembrane domain; the existence of a transmembrane region is however unproven.,enzyme regulation:Negatively regulated by hyperphosphorylation during mitosis. The hyperphosphorylated form does not associate with CCNB1-CDC2 complexes. The PLK1 protein kinase may be required for mitotic phosphorylation.,function:Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the cdc2 kinase specifically when cdc2 is complexed to cyclins. Mediates phosphorylation of cdc2 predominantly on 'Thr-14'. Also involved in Golgi fragmentation. May be involved in phosphorylation of cdc2 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be ind

  • Subcellular Location:

    Endoplasmic reticulum membrane ; Peripheral membrane protein . Golgi apparatus membrane ; Peripheral membrane protein .

  • Expression:

    Brain,Epithelium,PCR rescued clones,

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Catalog Number

  • Amount:100ul
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Myt 1 Polyclonal Antibody | EnoGene Biotech Co. Ltd