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Myotubularin Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-72952

  • Amount:

    100ul

  • Molecular Weight:

    69932Da

  • Applications:

    WB;IHC-p

  • Reactivity:

    Human;Mouse

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human Myotubularin. AA range:241-290

  • Source:

    Polyclonal, Rabbit

  • Western Blot analysis of various cells using Myotubularin Polyclonal Antibody diluted at 1:500

  • Gene Name:

    MTM1

  • Dilution:

    WB 1:500-2000;IHC-p 1:50-300

  • Protein Name:

    Myotubularin

  • Human Gene Id:

    4534

  • Human Swiss Prot No:

    Q13496

  • Mouse Gene Id:

    17772

  • Mouse Swiss Prot No:

    Q9Z2C5

  • Specificity:

    Myotubularin Polyclonal Antibody detects endogenous levels of Myotubularin protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    MTM1; CG2; Myotubularin

  • Observed Band(KD):

    70

  • Background:

    myotubularin 1(MTM1) Homo sapiens This gene encodes a dual-specificity phosphatase that acts on both phosphotyrosine and phosphoserine. It is required for muscle cell differentiation and mutations in this gene have been identified as being responsible for X-linked myotubular myopathy. [provided by RefSeq, Jul 2008],

  • Function:

    catalytic activity:Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.,caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,disease:Defects in MTM1 are the cause of X-linked centronuclear myopathy X-linked (XCNM) [MIM:310400]; also known as X-linked myotubular myopathy (XLMTM) or myotubular myopathy type 1 (MTM1). Centronuclear myopathies are congenital muscle disorders characterized by progressive muscular weakness and wasting involving mainly limb girdle, trunk, and neck muscles. It may also affect distal muscles. Weakness may be present during childhood or adolescence or may not become evident until the third decade of life. Ptosis is a frequent clinical feature. The most prominent histopathologic features include high frequency of centrally located nuclei in muscle fibers not secondary to r

  • Subcellular Location:

    Cytoplasm . Cell membrane; Peripheral membrane protein . Cell projection, filopodium . Cell projection, ruffle . Late endosome . Cytoplasm, myofibril, sarcomere . Localizes as a dense cytoplasmic network (PubMed:11001925). Also localizes to the plasma membrane, including plasma membrane extensions such as filopodia and ruffles (PubMed:12118066). Predominantly located in the cytoplasm following interaction with MTMR12 (PubMed:12847286). Recruited to the late endosome following EGF stimulation (PubMed:14722070). In skeletal muscles, co-localizes with MTMR12 in the sarcomere (By similarity). .

  • Expression:

    Epithelium,Platelet,Testis,

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Catalog Number

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Myotubularin Polyclonal Antibody | EnoGene Biotech Co. Ltd