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MYL3 Polyclonal Antibody
Datasheet
Catalog Number:
E20-72936Amount:
100ulMolecular Weight:
21932DaApplications:
WB;ELISA;IHC-pReactivity:
Human;Rat;Mouse;Purification:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.Immunogen:
The antiserum was produced against synthesized peptide derived from human MYL3. AA range:71-120Source:
Polyclonal, Rabbit
- Western Blot analysis of various cells using MYL3 Polyclonal Antibody
Gene Name:
MYL3Dilution:
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000Protein Name:
Myosin light chain 3Human Gene Id:
4634Human Swiss Prot No:
P08590Mouse Swiss Prot No:
P09542Specificity:
MYL3 Polyclonal Antibody detects endogenous levels of MYL3 protein.Formulation:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.Concentration:
1 mg/mlStorage Stability:
-20°C/1 yearOther Name:
MYL3; Myosin light chain 3; Cardiac myosin light chain 1; CMLC1; Myosin light chain 1; slow-twitch muscle B/ventricular isoform; MLC1SB; Ventricular/slow twitch myosin alkali light chainObserved Band(KD):
22Background:
myosin light chain 3(MYL3) Homo sapiens MYL3 encodes myosin light chain 3, an alkali light chain also referred to in the literature as both the ventricular isoform and the slow skeletal muscle isoform. Mutations in MYL3 have been identified as a cause of mid-left ventricular chamber type hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008],Function:
disease:Defects in MYL3 are the cause of cardiomyopathy familial hypertrophic type 8 (CMH8) [MIM:608751]. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. CMH8 inheritance can be autosomal dominant or recessive.,disease:Defects in MYL3 are the cause of cardiomyopathy hypertrophic with mid-left ventricular chamber type 1 (MVC1) [MIM:608751]. MVC1 is a very rare variant of familial hypertrophic cardiomyopathy, characterized by mid-left ventricular chamber thickening.,function:RegulatorySubcellular Location:
cytosol,muscle myosin complex,myosin complex,sarcomere,A band,I band,Expression:
Heart,Skeletal muscle,
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