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MYH Polyclonal Antibody
Datasheet
Catalog Number:
E20-72932Amount:
100ulMolecular Weight:
60069DaPurification:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.Immunogen:
The antiserum was produced against synthesized peptide derived from human MUTYH. AA range:151-200Source:
Polyclonal, Rabbit
- Western Blot analysis of various cells using MYH Polyclonal Antibody diluted at 1:1000 cells nucleus extracted by Minute TM Cytoplasmic and Nuclear Fractionation kit
Gene Name:
MUTYHDilution:
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.Protein Name:
A/G-specific adenine DNA glycosylaseHuman Gene Id:
4595Human Swiss Prot No:
Q9UIF7Mouse Gene Id:
70603Mouse Swiss Prot No:
Q99P21Rat Gene Id:
170841Rat Swiss Prot No:
Q8R5G2Specificity:
MYH Polyclonal Antibody detects endogenous levels of MYH protein.Formulation:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.Concentration:
1 mg/mlStorage Stability:
-20°C/1 yearOther Name:
MUTYH; MYH; A/G-specific adenine DNA glycosylase; MutY homolog; hMYHObserved Band(KD):
60Background:
mutY DNA glycosylase(MUTYH) Homo sapiens This gene encodes a DNA glycosylase involved in oxidative DNA damage repair. The enzyme excises adenine bases from the DNA backbone at sites where adenine is inappropriately paired with guanine, cytosine, or 8-oxo-7,8-dihydroguanine, a major oxidatively damaged DNA lesion. The protein is localized to the nucleus and mitochondria. Mutations in this gene result in heritable predisposition to colon and stomach cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],Function:
cofactor:Binds 1 4Fe-4S cluster. The cluster is not important for the catalytic activity, but which is probably involved in the proper positioning of the enzyme along the DNA strand.,disease:Defects in MUTYH are a cause of autosomal recessive colorectal adenomatous polyposis [MIM:608456].,disease:Defects in MUTYH are a cause of gastric cancer [MIM:137215].,function:Involved in oxidative DNA damage repair. Initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone. Possesses both adenine and 2-OH-A DNA glycosylase activities.,similarity:Belongs to the nth/mutY family.,similarity:Contains 1 nudix hydrolase domain.,Subcellular Location:
Nucleus . Mitochondrion .Expression:
Kidney,
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