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Myf-6 Polyclonal Antibody
Datasheet
Catalog Number:
E20-72931Amount:
100ulMolecular Weight:
26953DaPurification:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.Immunogen:
The antiserum was produced against synthesized peptide derived from human MYF6. AA range:116-165Source:
Polyclonal, Rabbit
- Western blot analysis of lysates from HepG2 and 293 cells, using MYF6 Antibody. The lane on the right is blocked with the synthesized peptide.
Gene Name:
MYF6Dilution:
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.Protein Name:
Myogenic factor 6Human Gene Id:
4618Human Swiss Prot No:
P23409Mouse Gene Id:
17878Mouse Swiss Prot No:
P15375Rat Gene Id:
25714Rat Swiss Prot No:
P19335Specificity:
Myf-6 Polyclonal Antibody detects endogenous levels of Myf-6 protein.Formulation:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.Concentration:
1 mg/mlStorage Stability:
-20°C/1 yearOther Name:
MYF6; BHLHC4; MRF4; Myogenic factor 6; Myf-6; Class C basic helix-loop-helix protein 4; bHLHc4; Muscle-specific regulatory factor 4Observed Band(KD):
26Background:
myogenic factor 6(MYF6) Homo sapiens The protein encoded by this gene is a probable basic helix-loop-helix (bHLH) DNA binding protein involved in muscle differentiation. The encoded protein likely acts as a heterodimer with another bHLH protein. Defects in this gene are a cause of autosomal dominant centronuclear myopathy (ADCNM). [provided by RefSeq, May 2010],Function:
disease:Defects in MYF6 may be a cause of centronuclear myopathy autosomal dominant (ADCNM) [MIM:160150]; also known as autosomal dominant myotubular myopathy. Centronuclear myopathies are congenital muscle disorders characterized by progressive muscular weakness and wasting involving mainly limb girdle, trunk, and neck muscles. It may also affect distal muscles. Weakness may be present during childhood or adolescence or may not become evident until the third decade of life. Ptosis is a frequent clinical feature. The most prominent histopathologic features include high frequency of centrally located nuclei in muscle fibers not secondary to regeneration, radial arrangement of sarcoplasmic strands around the central nuclei, and predominance and hypotrophy of type 1 fibers.,function:Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. PrSubcellular Location:
Nucleus.Expression:
Skeletal muscle.
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