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MyD88 Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-72928

  • Amount:

    100ul

  • Molecular Weight:

    (Da):33233

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human MyD88. AA range:171-220

  • Source:

    Polyclonal, Rabbit

  • Western Blot analysis of COLO205 cells using MyD88 Polyclonal Antibody diluted at 1:2000

  • Gene Name:

    MyD88

  • Dilution:

    IF: 1:50-200 Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunocytochemistry: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.

  • Protein Name:

    Myeloid differentiation primary response protein MyD88

  • Human Gene Id:

    4615

  • Human Swiss Prot No:

    Q99836

  • Mouse Gene Id:

    17874

  • Mouse Swiss Prot No:

    P22366

  • Rat Gene Id:

    301059

  • Rat Swiss Prot No:

    Q6Y1S1

  • Specificity:

    MyD88 Polyclonal Antibody detects endogenous levels of MyD88 protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    MYD88; Myeloid differentiation primary response protein MyD88

  • Observed Band(KD):

    33

  • Background:

    myeloid differentiation primary response 88(MYD88) Homo sapiens This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010],

  • Function:

    disease:Defects in MYD88 are the cause of MYD88 deficiency (MYD88D) [MIM:612260]; also called recurrent pyogenic bacterial infections due to MYD88 deficiency. Patients suffer from autosomal recessive, life-threatening, often recurrent pyogenic bacterial infections, including invasive pneumococcal disease, and die between 1 and 11 months of age. Surviving patients are otherwise healthy, with normal resistance to other microbes, and their clinical status improved with age.,function:Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. May be involved in myeloid differentiation.,similarity:Contains 1 death domain.,similarity:Contains 1 TIR domain.,subunit:Homodimer. Also forms hetero

  • Subcellular Location:

    Cytoplasm . Nucleus .

  • Expression:

    Ubiquitous.

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Catalog Number

  • Amount:100ul
  • Price:225$

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MyD88 Polyclonal Antibody | EnoGene Biotech Co. Ltd