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Sin3B Polyclonal Antibody
Datasheet
Catalog Number:
E20-72898Amount:
100ulMolecular Weight:
133066DaPurification:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.Immunogen:
The antiserum was produced against synthesized peptide derived from human SIN3B. AA range:221-270Source:
Polyclonal, Rabbit
- Western Blot analysis of various cells using Sin3B Polyclonal Antibody
Gene Name:
SIN3BDilution:
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000Protein Name:
Paired amphipathic helix protein Sin3bHuman Gene Id:
23309Human Swiss Prot No:
O75182Mouse Swiss Prot No:
Q62141Specificity:
Sin3B Polyclonal Antibody detects endogenous levels of Sin3B protein.Formulation:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.Concentration:
1 mg/mlStorage Stability:
-20°C/1 yearOther Name:
SIN3B; KIAA0700; Paired amphipathic helix protein Sin3b; Histone deacetylase complex subunit Sin3b; Transcriptional corepressor Sin3bObserved Band(KD):
130Background:
function:Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription.,similarity:Contains 3 PAH (paired amphipathic helix) repeats.,subunit:Interacts with FOXK1/MNF, MXI, MAD, NCOR1 and SAP30. Interaction with SDS3 enhances the interaction with HDAC1 to form a complex. Interacts with MAD3, MAD4, MAEL, REST and SETDB1 (By similarity). Interacts with HCFC1.,Function:
function:Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription.,similarity:Contains 3 PAH (paired amphipathic helix) repeats.,subunit:Interacts with FOXK1/MNF, MXI, MAD, NCOR1 and SAP30. Interaction with SDS3 enhances the interaction with HDAC1 to form a complex. Interacts with MAD3, MAD4, MAEL, REST and SETDB1 (By similarity). Interacts with HCFC1.,Subcellular Location:
Nucleus .Expression:
Brain,Duodenum,Lung,Skin,
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