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MRP-L41 Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-72863

  • Amount:

    100ul

  • Molecular Weight:

    15383Da

  • Applications:

    WB;IHC-p;IF(paraffin section);ELISA

  • Reactivity:

    Human;Mouse;Rat

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human MRPL41. AA range:81-130

  • Source:

    Polyclonal, Rabbit,IgG

  • Western Blot analysis of various cells using MRP-L41 Polyclonal Antibody

  • Gene Name:

    MRPL41

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.

  • Protein Name:

    39S ribosomal protein L41 mitochondrial

  • Human Gene Id:

    64975

  • Human Swiss Prot No:

    Q8IXM3

  • Mouse Gene Id:

    107733

  • Mouse Swiss Prot No:

    Q9CQN7

  • Rat Gene Id:

    296551

  • Rat Swiss Prot No:

    Q5BJX1

  • Specificity:

    MRP-L41 Polyclonal Antibody detects endogenous levels of MRP-L41 protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    MRPL41; BMRP; MRPL27; RPML27; PIG3; 39S ribosomal protein L41; mitochondrial; L41mt; MRP-L41; 39S ribosomal protein L27 homolog; Bcl-2-interacting mitochondrial ribosomal protein L41; Cell proliferation-inducing gene 3 protein; MRP-L27 homo

  • Observed Band(KD):

    21

  • Background:

    mitochondrial ribosomal protein L41(MRPL41) Homo sapiens Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the YmL27 ribosomal protein family. [provided by RefSeq, Jul 2008],

  • Function:

    function:Component of the mitochondrial ribosome large subunit. Also involved in apoptosis and cell cycle. Enhances TP53/p53 stability, thereby contributing to TP53/p53-induced apoptosis in response to growth-inhibitory condition. Enhances TP53/p53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins.,similarity:Belongs to the ribosomal protein L41 family.,subunit:Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins. Interacts with BCL2.,tissue specificity:Present in kidney, liver, thymus and testis, and at lower level in brain and spleen (at protein level).,

  • Subcellular Location:

    Mitochondrion .

  • Expression:

    Present in kidney, liver, thymus and testis, and at lower level in brain and spleen (at protein level).

  • Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using MRPL41 Antibody. The picture on the right is blocked with the synthesized peptide.

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