World supplier of antibodies, antigens and kits since 2007
Cell Signal Transduction Research Antibodies
MRP2 Polyclonal AntibodyAntibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight174191Da
Protein NameCanalicular multispecific organic anion transporter 1
Human Gene Id1244
Human Swiss Prot NoQ92887
Mouse Swiss Prot NoQ8VI47
SpecificityMRP2 Polyclonal Antibody detects endogenous levels of MRP2 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameABCC2; CMOAT; CMOAT1; CMRP; MRP2; Canalicular multispecific organic anion transporter 1; ATP-binding cassette sub-family C member 2; Canalicular multidrug resistance protein; Multidrug resistance-associated protein 2
Observed Band(KD)175
Functiondisease:Defects in ABCC2 are the cause of Dubin-Johnson syndrome (DJS) [MIM:237500]. DJS is an autosomal recessive disorder characterized by conjugated hyperbilirubinemia, an increase in the urinary excretion of coproporphyrin isomer I, deposition of melanin-like pigment in hepatocytes, and prolonged retention of sulfobromophthalein, but otherwise normal liver function.,function:Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter.,similarity:Belongs to the ABC transporter family. Conjugate transporter (TC 3.A.1.208) subfamily.,similarity:Contains 2 ABC transmembrane type-1 domains.,similarity:Contains 2 ABC transporter domains.,tissue specificity:Found on the apical membrane of polarized cells in liver, kidney and intestine. The highest expression is found in liver.,
Subcellular Locationplasma membrane,integral component of plasma membrane,cell surface,apical plasma membrane,intercellular canaliculus,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human ABCC2. AA range:991-1040
Gene NameABCC2
DilutionWestern Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
BackgroundATP binding cassette subfamily C member 2(ABCC2) Homo sapiens The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. [provided by RefSeq, Jul 2008],
Conjugated Antibody
This product is also available conjugated. Format: E20-72840-Conjugate. Price: $485 / Size: 100μl.
E20-72840-FITC$485 / 100μlE20-72840-Biotin$485 / 100μlE20-72840-HRP$485 / 100μlE20-72840-AP$485 / 100μlE20-72840-AF350$485 / 100μlE20-72840-AF405M$485 / 100μlE20-72840-AF488$485 / 100μlE20-72840-AF514$485 / 100μlE20-72840-AF532$485 / 100μlE20-72840-AF555$485 / 100μlE20-72840-AF568$485 / 100μlE20-72840-AF405S$485 / 100μlE20-72840-AF405L$485 / 100μlE20-72840-AF546$485 / 100μlE20-72840-AF594$485 / 100μlE20-72840-AF610$485 / 100μlE20-72840-AF635$485 / 100μlE20-72840-AF647$485 / 100μlE20-72840-AF680$485 / 100μlE20-72840-AF700$485 / 100μlE20-72840-AF750$485 / 100μlE20-72840-AF790$485 / 100μlE20-72840-APC$485 / 100μlE20-72840-PE$485 / 100μlE20-72840-Cy3$485 / 100μlE20-72840-Cy5$485 / 100μlE20-72840-Cy5.5$485 / 100μlE20-72840-Cy7$485 / 100μlE20-72840-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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