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Mnk1 Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-72805

  • Amount:

    100ul

  • Molecular Weight:

    51342Da

  • Applications:

    WB;IHC-p;IF(paraffin section);ELISA

  • Reactivity:

    Human;Mouse

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human MKNK1. AA range:111-160

  • Source:

    Polyclonal, Rabbit,IgG

  • Western Blot analysis of various cells using Mnk1 Polyclonal Antibody diluted at 1:500

  • Gene Name:

    MKNK1

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.

  • Protein Name:

    MAP kinase-interacting serine/threonine-protein kinase 1

  • Human Gene Id:

    8569

  • Human Swiss Prot No:

    Q9BUB5

  • Mouse Gene Id:

    17346

  • Mouse Swiss Prot No:

    O08605

  • Specificity:

    Mnk1 Polyclonal Antibody detects endogenous levels of Mnk1 protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    MKNK1; MNK1; MAP kinase-interacting serine/threonine-protein kinase 1; MAP kinase signal-integrating kinase 1; MAPK signal-integrating kinase 1; Mnk1

  • Observed Band(KD):

    51

  • Background:

    MAP kinase interacting serine/threonine kinase 1(MKNK1) Homo sapiens This gene encodes a Ser/Thr protein kinase that interacts with, and is activated by ERK1 and p38 mitogen-activated protein kinases, and thus may play a role in the response to environmental stress and cytokines. This kinase may also regulate transcription by phosphorylating eIF4E via interaction with the C-terminal region of eIF4G. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Jan 2012],

  • Function:

    catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Phosphorylated and activated by the p38 kinases and kinases in the Erk pathway.,function:May play a role in the response to environmental stress and cytokines. Appears to regulate transcription by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap.,PTM:Dual phosphorylation of Thr-250 and Thr-255 activates the kinase. Phosphorylation of Thr-385 activates the kinase.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.,similarity:Contains 1 protein kinase domain.,subunit:Interacts with the C-terminal regions of EIF4G1 and EIF4G2. Also binds to dephosphorylated ERK1 and ERK2, and to the p38 kinases.,tissue specificity:Ubiquitous.,

  • Subcellular Location:

    [Isoform 2]: Cytoplasm.; [Isoform 3]: Cytoplasm. Nucleus.

  • Expression:

    Ubiquitous.

  • Western Blot analysis of HuvEc cells using Mnk1 Polyclonal Antibody diluted at 1:500

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