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MMP-11 Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-72794

  • Amount:

    100ul

  • Molecular Weight:

    54618Da

  • Applications:

    WB;IHC-p;IF/ICC;ELISA

  • Reactivity:

    Human;Rat;Mouse;

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human MMP-11. AA range:61-110

  • Source:

    Polyclonal, Rabbit,IgG

  • Western Blot analysis of various cells using MMP-11 Polyclonal Antibody diluted at 1:500

  • Gene Name:

    MMP11

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.

  • Protein Name:

    Stromelysin-3

  • Human Gene Id:

    4320

  • Human Swiss Prot No:

    P24347

  • Mouse Gene Id:

    17385

  • Mouse Swiss Prot No:

    Q02853

  • Rat Gene Id:

    25481

  • Rat Swiss Prot No:

    Q499S5

  • Specificity:

    MMP-11 Polyclonal Antibody detects endogenous levels of MMP-11 protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    MMP11; STMY3; Stromelysin-3; SL-3; ST3; Matrix metalloproteinase-11; MMP-11

  • Observed Band(KD):

    60

  • Background:

    Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is activated intracellularly by furin within the constitutive secretory pathway. Also in contrast to other MMP's, this enzyme cleaves alpha 1-proteinase inhibitor but weakly degrades structural proteins of the extracellular matrix. [provided by RefSeq, Jul 2008],

  • Function:

    cofactor:Binds 1 calcium ion per subunit.,cofactor:Binds 2 zinc ions per subunit.,domain:The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.,function:May play an important role in the progression of epithelial malignancies.,PTM:The precursor is cleaved by a furin endopeptidase.,similarity:Belongs to the peptidase M10A family.,similarity:Contains 4 hemopexin-like domains.,tissue specificity:Specifically expressed in stromal cells of breast carcinomas.,

  • Subcellular Location:

    Secreted, extracellular space, extracellular matrix .

  • Expression:

    Specifically expressed in stromal cells of breast carcinomas.

  • Immunohistochemical analysis of paraffin-embedded Human lung cancer. Antibody was diluted at 1:100(4° overnight). High-pressure and temperature Tris-EDTA,pH8.0 was used for antigen retrieval. Negetive contrl (right) obtaned from antibody was pre-absorbed by immunogen peptide.

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Catalog Number

  • Amount:100ul
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MMP-11 Polyclonal Antibody | EnoGene Biotech Co. Ltd