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MLTK Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-72789

  • Amount:

    100ul

  • Price:

    225$

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human ZAK. AA range:131-180

  • Source:

    Polyclonal, Rabbit

  • Gene Name:

    MLTK

  • Dilution:

    Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.

  • Western blot analysis of lysates from Jurkat cells, using ZAK Antibody. The lane on the right is blocked with the synthesized peptide.

  • Background:

    sterile alpha motif and leucine zipper containing kinase AZK(ZAK) Homo sapiens This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008],

  • Protein Name:

    Mitogen-activated protein kinase kinase kinase MLT

  • Human Gene Id:

    51776

  • Human Swiss Prot No:

    Q9NYL2

  • Mouse Gene Id:

    65964

  • Mouse Swiss Prot No:

    Q9ESL4

  • Specificity:

    MLTK Polyclonal Antibody detects endogenous levels of MLTK protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    MLTK; ZAK; HCCS4; Mitogen-activated protein kinase kinase kinase MLT; Human cervical cancer suppressor gene 4 protein; HCCS-4; Leucine zipper- and sterile alpha motif-containing kinase; MLK-like mitogen-activated protein triple kinase; Mixe

  • MolecularWeight(Da):

    91181

  • Observed Band(KD):

    91

  • Function:

    catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Activated by phosphorylation by PKN1 and autophosphorylation on Thr-161 and Ser-165.,function:Stress-activated component of a protein kinase signal transduction cascade. Regulates the JNK and p38 pathways. Pro-apoptotic. Role in regulation of S and G2 cell cycle checkpoint by direct phosphorylation of CHEK2. Isoform 1, but not isoform 2, causes cell shrinkage and disruption of actin stress fibers. Isoform 1 may have role in neoplastic cell transformation and cancer development. Isoform 1, but not isoform 2, phosphorylates histone H3 at 'Ser-28'.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SAM (sterile alpha motif) domain.,subcellular location:Tr

  • Subcellular Location:

    intracellular,nucleus,cytoplasm,

  • Expression:

    Brain,Colon,Epithelium,Fetal brain,Heart,Ly,

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Catalog Number

  • Amount:100ul
  • Price:225$

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MLTK Polyclonal Antibody | EnoGene Biotech Co. Ltd