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MLKL Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-72788

  • Amount:

    100ul

  • Molecular Weight:

    54479Da

  • Applications:

    WB;IHC-p

  • Reactivity:

    Human;Rat;Mouse;

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    Synthesized peptide derived from MLKL . at AA range: 40-120

  • Source:

    Polyclonal, Rabbit,IgG

  • Western Blot analysis of various cells using MLKL Polyclonal Antibody diluted at 1:500

  • Gene Name:

    MLKL

  • Dilution:

    WB 1:500-2000;IHC-p 1:50-300

  • Protein Name:

    Mixed lineage kinase domain-like protein

  • Human Gene Id:

    197259

  • Human Swiss Prot No:

    Q8NB16

  • Mouse Swiss Prot No:

    Q9D2Y4

  • Specificity:

    MLKL Polyclonal Antibody detects endogenous levels of MLKL protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    MLKL; Mixed lineage kinase domain-like protein

  • Observed Band(KD):

    55

  • Background:

    This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015],

  • Function:

    domain:The protein kinase domain is predicted to be catalytically inactive.,similarity:Belongs to the protein kinase superfamily.,similarity:Contains 1 protein kinase domain.,

  • Subcellular Location:

    Cytoplasm . Cell membrane . Nucleus . Localizes to the cytoplasm and translocates to the plasma membrane on necroptosis induction (PubMed:24316671). Localizes to the nucleus in response to orthomyxoviruses infection (By similarity). .

  • Expression:

    Chondrocyte,Leukocyte,Lymph node,

  • Immunohistochemical analysis of paraffin-embedded human liver cancer. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).

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Catalog Number

  • Amount:100ul
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