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MLK3 Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-72786

  • Amount:

    100ul

  • Price:

    225$

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human MLK3. AA range:640-689

  • Source:

    Polyclonal, Rabbit

  • Gene Name:

    MAP3K11

  • Dilution:

    Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.

  • Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using MLK3 Antibody. The picture on the right is blocked with the synthesized peptide.

  • Background:

    mitogen-activated protein kinase kinase kinase 11(MAP3K11) Homo sapiens The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42. [provided by RefSeq, Jul 2008],

  • Protein Name:

    Mitogen-activated protein kinase kinase kinase 11

  • Human Gene Id:

    4296

  • Human Swiss Prot No:

    Q16584

  • Mouse Gene Id:

    26403

  • Mouse Swiss Prot No:

    Q80XI6

  • Rat Gene Id:

    309168

  • Rat Swiss Prot No:

    Q66HA1

  • Specificity:

    MLK3 Polyclonal Antibody detects endogenous levels of MLK3 protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    MAP3K11; MLK3; PTK1; SPRK; Mitogen-activated protein kinase kinase kinase 11; Mixed lineage kinase 3; Src-homology 3 domain-containing proline-rich kinase

  • MolecularWeight(Da):

    92688

  • Function:

    catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Homodimerization via the leucine zipper domains is required for autophosphorylation and subsequent activation.,function:Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1). Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle.,PTM:Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation. Thr-277 is likely to be the main autophosphorylation site. Phosphorylation of Ser-555 and Ser-556 is induced by CDC42.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP

  • Subcellular Location:

    intracellular,cytoplasm,centrosome,microtubule,membrane,

  • Expression:

    Brain,Epithelium,Hippocampus,Liver,Megakaryocyte,Sp

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Catalog Number

  • Amount:100ul
  • Price:225$

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