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MLK1 Polyclonal Antibody
Datasheet
Catalog Number:
E20-72783Amount:
100ulPrice:
225$Purification:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.Immunogen:
The antiserum was produced against synthesized peptide derived from human MAP3K9. AA range:561-610Source:
Polyclonal, RabbitGene Name:
MAP3K9Dilution:
Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.
- Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue, using MAP3K9 Antibody. The picture on the right is blocked with the synthesized peptide.
Background:
MAP3K9 (Mitogen-Activated Protein Kinase Kinase Kinase 9) is a Protein Coding gene. Diseases associated with MAP3K9 include retroperitoneal neuroblastoma. Among its related pathways are MAP Kinase Signaling andTGF-Beta Pathway. GO annotations related to this gene include protein homodimerization activity and protein kinase activity. An important paralog of this gene is KSR1.Protein Name:
Mitogen-activated protein kinase kinase kinase 9Human Gene Id:
4293Human Swiss Prot No:
P80192Mouse Gene Id:
338372Mouse Swiss Prot No:
Q3U1V8Specificity:
MLK1 Polyclonal Antibody detects endogenous levels of MLK1 protein.Formulation:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.Concentration:
1 mg/mlStorage Stability:
-20°C/1 yearOther Name:
MAP3K9; MLK1; PRKE1; Mitogen-activated protein kinase kinase kinase 9; Mixed lineage kinase 1MolecularWeight(Da):
121895Function:
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Homodimerization via the leucine zipper domains is required for autophosphorylation and subsequent activation.,function:Activates the JUN N-terminal pathway.,PTM:Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation. Thr-312 is likely to be the main autophosphorylation site.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SH3 domain.,subunit:Homodimer.,tissue specificity:Expressed in epithelial tumor cell lines of colonic, breast and esophageal origin.,Subcellular Location:
intracellular,integral component of membrane,Expression:
Colon epithelium,Spleen,
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