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MKP-3 Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-72774

  • Amount:

    100ul

  • Molecular Weight:

    42320Da

  • Price:

    225$

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human DUSP6. AA range:61-110

  • Source:

    Polyclonal, Rabbit

  • Western Blot analysis of HEPG2-UV cells using MKP-3 Polyclonal Antibody diluted at 1:500

  • Gene Name:

    DUSP6

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.

  • Protein Name:

    Dual specificity protein phosphatase 6 Human Gene Id:1848

  • Human Swiss Prot No:

    Q16828

  • Specificity:

    MKP-3 Polyclonal Antibody detects endogenous levels of MKP-3 protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    DUSP6; MKP3; PYST1; Dual specificity protein phosphatase 6; Dual specificity protein phosphatase PYST1; Mitogen-activated protein kinase phosphatase 3; MAP kinase phosphatase 3; MKP-3

  • Observed Band(KD):

    42

  • Background:

    dual specificity phosphatase 6(DUSP6) Homo sapiens The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Mutations in t

  • Function:

    catalytic activity:A phosphoprotein + H(2)O = a protein + phosphate.,catalytic activity:Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.,function:Inactivates MAP kinases. Has a specificity for the ERK family.,similarity:Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.,similarity:Contains 1 rhodanese domain.,similarity:Contains 1 tyrosine-protein phosphatase domain.,

  • Subcellular Location:

    nucleoplasm,cytoplasm,cytosol,

  • Expression:

    Colon,Foreskin,Kidney,Liver,Skin,Stomach,

  • Immunofluorescence analysis of HeLa cells, using DUSP6 Antibody. The picture on the right is blocked with the synthesized peptide.

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Catalog Number

  • Amount:100ul
  • Price:225$

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MKP-3 Polyclonal Antibody | EnoGene Biotech Co. Ltd