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MK Polyclonal Antibody
Datasheet
Catalog Number:
E20-72770Amount:
100ulMolecular Weight:
15,585DaApplications:
WB;ELISA;IHC-pReactivity:
Human;RatPurification:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.Immunogen:
The antiserum was produced against synthesized peptide derived from human MK. AA range:94-143Source:
Polyclonal, Rabbit,IgG
- Western Blot analysis of various cells using MK Polyclonal Antibody diluted at 1:2000
Gene Name:
MDKDilution:
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000Protein Name:
MidkineHuman Gene Id:
4192Human Swiss Prot No:
P21741Mouse Swiss Prot No:
P12025Rat Gene Id:
81517Rat Swiss Prot No:
Q9R1S9Specificity:
MK Polyclonal Antibody detects endogenous levels of MK protein.Formulation:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.Concentration:
1 mg/mlStorage Stability:
-20°C/1 yearOther Name:
MDK; MK1; NEGF2; Midkine; MK; Amphiregulin-associated protein; ARAP; Midgestation and kidney protein; Neurite outgrowth-promoting factor 2; Neurite outgrowth-promoting proteinObserved Band(KD):
18Background:
This gene encodes a member of a small family of secreted growth factors that binds heparin and responds to retinoic acid. The encoded protein promotes cell growth, migration, and angiogenesis, in particular during tumorigenesis. This gene has been targeted as a therapeutic for a variety of different disorders. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2012],Function:
function:Has heparin binding activity, and growth promoting activity. Involved in neointima formation after arterial injury, possibly by mediating leukocyte recruitment. Also involved in early fetal adrenal gland development.,induction:By heparin and retinoic acid.,similarity:Belongs to the pleiotrophin family.,subunit:Homodimer.,Subcellular Location:
Secreted.Expression:
Expressed in various tumor cell lines. In insulinoma tissue predominantly expressed in precancerous lesions.
- Western blot analysis of lysate from 293 cells, using MK antibody.
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