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MIPP Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-72767

  • Amount:

    100ul

  • Molecular Weight:

    55051Da

  • Applications:

    WB;IHC-p;IF(paraffin section);ELISA

  • Reactivity:

    Human;Mouse;Rat

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human MINPP1. AA range:328-377

  • Source:

    Polyclonal, Rabbit,IgG

  • Western Blot analysis of various cells using MIPP Polyclonal Antibody

  • Gene Name:

    MINPP1

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.

  • Protein Name:

    Multiple inositol polyphosphate phosphatase 1

  • Human Gene Id:

    9562

  • Human Swiss Prot No:

    Q9UNW1

  • Mouse Gene Id:

    17330

  • Mouse Swiss Prot No:

    Q9Z2L6

  • Rat Gene Id:

    29688

  • Rat Swiss Prot No:

    O35217

  • Specificity:

    MIPP Polyclonal Antibody detects endogenous levels of MIPP protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    MINPP1; MIPP; Multiple inositol polyphosphate phosphatase 1; 2; 3-bisphosphoglycerate 3-phosphatase; 2,3-BPG phosphatase; Inositol; 1,3,4,5)-tetrakisphosphate 3-phosphatase; Ins(1,3,4,5)P(4) 3-phosphatase

  • Observed Band(KD):

    60

  • Background:

    This gene encodes multiple inositol polyphosphate phosphatase; an enzyme that removes 3-phosphate from inositol phosphate substrates. It is the only enzyme known to hydrolzye inositol pentakisphosphate and inositol hexakisphosphate. This enzyme also converts 2,3 bisphosphoglycerate (2,3-BPG) to 2-phosphoglycerate; an activity formerly thought to be exclusive to 2,3-BPG synthase/2-phosphatase (BPGM) in the Rapoport-Luebering shunt of the glycolytic pathway.[provided by RefSeq, Sep 2009],

  • Function:

    catalytic activity:Myo-inositol hexakisphosphate + H(2)O = myo-inositol pentakisphosphate (mixed isomers) + phosphate.,disease:Defects in MINPP1 may be involved in follicular thyroid tumors development.,function:Acts as a phosphoinositide 5- and phosphoinositide 6-phosphatase and regulates cellular levels of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6) (By similarity). May play a role in bone development (endochondral ossification).,tissue specificity:Widely expressed with highest levels in kidney, liver and placenta.,

  • Subcellular Location:

    Endoplasmic reticulum lumen .

  • Expression:

    Widely expressed with highest levels in kidney, liver and placenta.

  • Western blot analysis of lysates from 293 cells, using MINPP1 Antibody. The lane on the right is blocked with the synthesized peptide.

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