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MIF Polyclonal Antibody
Datasheet
Catalog Number:
E20-72762Amount:
100ulPrice:
225$Purification:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.Immunogen:
Synthesized peptide derived from MIF . at AA range: 30-110Source:
Polyclonal, RabbitGene Name:
MIFDilution:
WB 1:500-2000 Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.Background:
macrophage migration inhibitory factor (glycosylation-inhibiting factor)(MIF) Homo sapiens This gene encodes a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation. It plays a role in the regulation of macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids. This lymphokine and the JAB1 protein form a complex in the cytosol near the peripheral plasma membrane, which may indicate an additional role in integrin signaling pathways. [provided by RefSeq, Jul 2008],Protein Name:
Macrophage migration inhibitory factorHuman Gene Id:
4282Human Swiss Prot No:
P14174Mouse Gene Id:
17319Mouse Swiss Prot No:
P34884Rat Gene Id:
81683Rat Swiss Prot No:
P30904Specificity:
MIF Polyclonal Antibody detects endogenous levels of MIF protein.Formulation:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.Concentration:
1 mg/mlStorage Stability:
-20°C/1 yearOther Name:
MIF; GLIF; MMIF; Macrophage migration inhibitory factor; MIF; Glycosylation-inhibiting factor; GIF; L-dopachrome isomerase; L-dopachrome tautomerase; Phenylpyruvate tautomeraseMolecularWeight(Da):
12476Function:
catalytic activity:Keto-phenylpyruvate = enol-phenylpyruvate.,disease:Genetic variations in MIF are associated with susceptibility to systemic juvenile rheumatoid arthritis [MIM:604302]. Systemic juvenile rheumatoid arthritis is juvenile chronic arthritis associated with severe, debilitating, extraarticular features, and occasionally fatal complications. Despite medical treatment, many children still experience early joint destruction, necessitating surgical replacement.,function:The expression of MIF at sites of inflammation suggest a role for the mediator in regulating the function of macrophage in host defense. Also acts as a phenylpyruvate tautomerase.,similarity:Belongs to the MIF family.,subunit:Homotrimer. Interacts with COPS5 and BNIPL.,Subcellular Location:
extracellular region,extracellular space,nucleoplasm,cytoplasm,cell surface,vesicle,myelin sheath,extracellular exosome,Expression:
Brain,Lens,Liver,Lung,Platelet,Skin
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Catalog Number
- Amount:100ul
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