World supplier of antibodies, antigens and kits since 2007
Cell Signal Transduction Research Antibodies
Mi2-β Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight217991Da
Protein NameChromodomain-helicase-DNA-binding protein 4
Human Gene Id1108
Human Swiss Prot NoQ14839
Mouse Gene Id107932
Mouse Swiss Prot NoQ6PDQ2
SpecificityMi2-β Polyclonal Antibody detects endogenous levels of Mi2-β protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameCHD4; Chromodomain-helicase-DNA-binding protein 4; CHD-4; ATP-dependent helicase CHD4; Mi-2 autoantigen 218 kDa protein; Mi2-beta
Functiondisease:One of the main antigens reacting with anti-MI-2 positive sera of dermatomyositis.,function:Probable transcription regulator.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the SNF2/RAD54 helicase family.,similarity:Contains 1 helicase ATP-binding domain.,similarity:Contains 1 helicase C-terminal domain.,similarity:Contains 2 chromo domains.,similarity:Contains 2 PHD-type zinc fingers.,subunit:Central component of the nucleosome remodeling and histone deacetylase (NuRD) repressor complex. Interacts with TRIM27. Part of a complex containing ATR and HDAC2. Interacts with KLF1; the interaction depends on sumoylation of KLF1, and leads to its transcriptional repression.,
Subcellular Locationnuclear chromatin,nucleus,nucleoplasm,cytoplasm,centrosome,membrane,NuRD complex,protein-DNA complex,protein complex,
ExpressionEpithelium,Pancreas,Skin,Uterus,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human CHD4. AA range:571-620
Gene NameCHD4
DilutionImmunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Backgroundchromodomain helicase DNA binding protein 4(CHD4) Homo sapiens The product of this gene belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Patients with dermatomyositis develop antibodies against this protein. Somatic mutations in this gene are associated with serous endometrial tumors. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014],
Conjugated Antibody
This product is also available conjugated. Format: E20-72754-Conjugate. Price: $485 / Size: 100μl.
E20-72754-FITC$485 / 100μlE20-72754-Biotin$485 / 100μlE20-72754-HRP$485 / 100μlE20-72754-AP$485 / 100μlE20-72754-AF350$485 / 100μlE20-72754-AF405M$485 / 100μlE20-72754-AF488$485 / 100μlE20-72754-AF514$485 / 100μlE20-72754-AF532$485 / 100μlE20-72754-AF555$485 / 100μlE20-72754-AF568$485 / 100μlE20-72754-AF405S$485 / 100μlE20-72754-AF405L$485 / 100μlE20-72754-AF546$485 / 100μlE20-72754-AF594$485 / 100μlE20-72754-AF610$485 / 100μlE20-72754-AF635$485 / 100μlE20-72754-AF647$485 / 100μlE20-72754-AF680$485 / 100μlE20-72754-AF700$485 / 100μlE20-72754-AF750$485 / 100μlE20-72754-AF790$485 / 100μlE20-72754-APC$485 / 100μlE20-72754-PE$485 / 100μlE20-72754-Cy3$485 / 100μlE20-72754-Cy5$485 / 100μlE20-72754-Cy5.5$485 / 100μlE20-72754-Cy7$485 / 100μlE20-72754-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
Categories by research area
Categories by product type
- Antibodies
- Tag antibodies
- Internal control antibodies
- Pathological (Immunohistochemistry, IHC) antibodies
- Cell Signal Transduction Research Antibodies
- Secondary Antibody
- Antibody Sampler Kits
- Recombinant Proteins
- Fluorescence Reagents
- Signal Inhibitors and Activators
- Transfection Reagent
- Cell biology kits