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MerTK Polyclonal Antibody
Datasheet
Catalog Number:
E20-72733Amount:
100ulMolecular Weight:
110249DaApplications:
WB;ELISA;IHC-pReactivity:
Human;Mouse;RatPurification:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.Immunogen:
The antiserum was produced against synthesized peptide derived from human MERTK. AA range:10-59Source:
Polyclonal, Rabbit,IgG
- Western Blot analysis of various cells using MerTK Polyclonal Antibody diluted at 1:2000
Gene Name:
MERTKDilution:
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000Protein Name:
Tyrosine-protein kinase MerHuman Gene Id:
10461Human Swiss Prot No:
Q12866Mouse Swiss Prot No:
Q60805Specificity:
MerTK Polyclonal Antibody detects endogenous levels of MerTK protein.Formulation:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.Concentration:
1 mg/mlStorage Stability:
-20°C/1 yearOther Name:
MERTK; MER; Tyrosine-protein kinase Mer; Proto-oncogene c-Mer; Receptor tyrosine kinase MerTKObserved Band(KD):
110Background:
This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP). [provided by RefSeq, Jul 2008],Function:
catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,disease:Defects in MERTK are a cause of retinitis pigmentosa (RP) [MIM:268000]. RP that leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.,function:In case of filovirus infection, seems to function as a cell entry factor.,online information:Retina International's Scientific Newsletter,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 2 fibronectin type-III domains.,similarity:Contains 2 Ig-like C2-type (immSubcellular Location:
Cell membrane ; Single-pass type I membrane protein .Expression:
Not expressed in normal B- and T-lymphocytes but is expressed in numerous neoplastic B- and T-cell lines. Highly expressed in testis, ovary, prostate, lung, and kidney, with lower expression in spleen, small intestine, colon, and liver.
- Western Blot analysis of HEPG2 cells using MerTK Polyclonal Antibody diluted at 1:2000
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