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Mena Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-72731

  • Amount:

    100ul

  • Price:

    225$

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human ENAH. AA range:472-521

  • Source:

    Polyclonal, Rabbit

  • Western Blot analysis of 293 cells using Mena Polyclonal Antibody diluted at 1:2000

  • Gene Name:

    ENAH

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.

  • Background:

    enabled homolog (Drosophila)(ENAH) Homo sapiens This gene encodes a member of the enabled/ vasodilator-stimulated phosphoprotein. Members of this gene family are involved in actin-based motility. This protein is involved in regulating the assembly of actin filaments and modulates cell adhesion and motility. Alternate splice variants of this gene have been correlated with tumor invasiveness in certain tissues and these variants may serve as prognostic markers. A pseudogene of this gene is found on chromosome 3. [provided by RefSeq, Sep 2016],

  • Protein Name:

    Protein enabled homolog

  • Human Gene Id:

    55740

  • Human Swiss Prot No:

    Q8N8S7

  • Mouse Gene Id:

    13800

  • Mouse Swiss Prot No:

    Q03173

  • Specificity:

    Mena Polyclonal Antibody detects endogenous levels of Mena protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    ENAH; MENA; Protein enabled homolog

  • MolecularWeight(Da):

    66510

  • Observed Band(KD):

    67

  • Function:

    domain:The EVH2 domain is comprised of 3 regions. Block A is a thymosin-like domain required for G-actin binding. The KLKR motif within this block is essential for the G-actin binding and for actin polymerization. Block B is required for F-actin binding and subcellular location, and Block C for tetramerization.,function:Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. ENAH induces the formation of F-actin rich outgrowths in fibroblasts. Acts syngeristically with BAIAP2-alpha and downstream of NTN1 to promote filipodia formation. Required for the actin-based mobility of Listeria monocytogenes.,PTM:NTN1-induced PKA phosphorylation on Ser-265 directly parallels the formation of filopodial protrusions.,PTM:Phosphorylated up

  • Subcellular Location:

    cytoplasm,cytosol,cytoskeleton,plasma membrane,focal adhesion,lamellipodium,cell junction,filopodium,synapse,

  • Expression:

    Amygdala,Epithelium,Mammary tumor,Placenta,Skin,T-cell,Teratocarcinoma,Test

  • Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using ENAH Antibody. The picture on the right is blocked with the synthesized peptide.

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Catalog Number

  • Amount:100ul
  • Price:225$

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Mena Polyclonal Antibody | EnoGene Biotech Co. Ltd