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Meis1 Polyclonal Antibody
Datasheet
Catalog Number:
E20-72706Amount:
100ulPrice:
225$Purification:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.Immunogen:
The antiserum was produced against synthesized peptide derived from human Meis1. AA range:229-278Source:
Polyclonal, Rabbit
- Western blot analysis of K562 lysis using Meis1 antibody. Antibody was diluted at 1:1000 cells nucleus extracted by Minute TM Cytoplasmic and Nuclear Fractionation kit (SC-003,Inventbiotech,MN,USA).
Gene Name:
MEIS1Dilution:
Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.Background:
Meis homeobox 1(MEIS1) Homo sapiens Homeobox genes, of which the most well-characterized category is represented by the HOX genes, play a crucial role in normal development. In addition, several homeoproteins are involved in neoplasia. This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. [provided by RefSeq, Jul 2008],Protein Name:
Homeobox protein Meis1Human Gene Id:
4211Human Swiss Prot No:
O00470Mouse Gene Id:
17268Mouse Swiss Prot No:
Q60954Specificity:
Meis1 Polyclonal Antibody detects endogenous levels of Meis1 protein.Formulation:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.Concentration:
1 mg/mlStorage Stability:
-20°C/1 yearOther Name:
MEIS1; Homeobox protein Meis1MolecularWeight(Da):
43016Observed Band(KD):
37Function:
function:Acts as a transcriptional regulator of PAX6. Acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias.,similarity:Belongs to the TALE/MEIS homeobox family.,similarity:Contains 1 homeobox DNA-binding domain.,subunit:Interacts with the N-terminal region of PBX1 to form a heterodimer which binds DNA including a cAMP-responsive sequence in CYP17. Also forms heterodimers with PBX2. Forms heterotrimers with PBX1 or PBX2 and a number of HOX proteins including HOXA9, HOXD4 and HOXD9 where it acts as a non-DNA-binding partner. Also forms heterotrimers with PBX1 and HOX proteins including HOXD9 and HOXD10 where PBX1 is the non-DNA-binding partner.,tissue specificity:Expressed at low level in normal immunSubcellular Location:
nucleus,transcription factor complex,Expression:
Placenta,Uterus,
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Catalog Number
- Amount:100ul
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