World supplier of antibodies, antigens and kits since 2007
Cell Signal Transduction Research Antibodies
Med8 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight29080DaObserved Band:29KD
Protein NameMediator of RNA polymerase II transcription subunit 8
Human Gene Id112950
Human Swiss Prot NoQ96G25
Mouse Gene Id80509
Mouse Swiss Prot NoQ9D7W5
SpecificityMed8 Polyclonal Antibody detects endogenous levels of Med8 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameMED8; Mediator of RNA polymerase II transcription subunit 8; Activator-recruited cofactor 32 kDa component; ARC32; Mediator complex subunit 8
Functiondomain:The elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x(3)-C-x(3)-[AILV].,function:Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May play a role as a target recruitment subunit in E3 ubiquitin-protein ligase complexes and thus in ubiquitination and subsequent proteasomal degradation of target proteins.,pathway:Protein modification; protein ubiquitination.,similarity:Belongs to the Mediator
Subcellular Locationnucleoplasm,mediator complex,
ExpressionCervix carcinoma,Melanoma,Testis,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenSynthesized peptide derived from Med8 . at AA range: 70-150
Gene NameMED8
DilutionWestern Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications
Backgroundmediator complex subunit 8(MED8) Homo sapiens This gene encodes a protein component of the mediator complex, which aids in transcriptional activation through interaction with RNA polymerase II and gene-specific transcription factors. The encoded protein may also function in ubiquitin ligation and protein degradation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2013],
Conjugated Antibody
This product is also available conjugated. Format: E20-72697-Conjugate. Price: $485 / Size: 100μl.
E20-72697-FITC$485 / 100μlE20-72697-Biotin$485 / 100μlE20-72697-HRP$485 / 100μlE20-72697-AP$485 / 100μlE20-72697-AF350$485 / 100μlE20-72697-AF405M$485 / 100μlE20-72697-AF488$485 / 100μlE20-72697-AF514$485 / 100μlE20-72697-AF532$485 / 100μlE20-72697-AF555$485 / 100μlE20-72697-AF568$485 / 100μlE20-72697-AF405S$485 / 100μlE20-72697-AF405L$485 / 100μlE20-72697-AF546$485 / 100μlE20-72697-AF594$485 / 100μlE20-72697-AF610$485 / 100μlE20-72697-AF635$485 / 100μlE20-72697-AF647$485 / 100μlE20-72697-AF680$485 / 100μlE20-72697-AF700$485 / 100μlE20-72697-AF750$485 / 100μlE20-72697-AF790$485 / 100μlE20-72697-APC$485 / 100μlE20-72697-PE$485 / 100μlE20-72697-Cy3$485 / 100μlE20-72697-Cy5$485 / 100μlE20-72697-Cy5.5$485 / 100μlE20-72697-Cy7$485 / 100μlE20-72697-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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