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ME2 Polyclonal Antibody
Datasheet
Catalog Number:
E20-72694Amount:
100ulPrice:
225$Purification:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.Immunogen:
The antiserum was produced against synthesized peptide derived from human ME2. AA range:201-250Source:
Polyclonal, RabbitGene Name:
ME2Dilution:
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.
- Immunohistochemistry analysis of paraffin-embedded human placenta tissue, using ME2 Antibody. The picture on the right is blocked with the synthesized peptide.
Background:
malic enzyme 2(ME2) Homo sapiens This gene encodes a mitochondrial NAD-dependent malic enzyme, a homotetrameric protein, that catalyzes the oxidative decarboxylation of malate to pyruvate. It had previously been weakly linked to a syndrome known as Friedreich ataxia that has since been shown to be the result of mutation in a completely different gene. Certain single-nucleotide polymorphism haplotypes of this gene have been shown to increase the risk for idiopathic generalized epilepsy. Alternatively spliced transcript variants encoding different isoforms found for this gene. [provided by RefSeq, Dec 2009],Protein Name:
NAD-dependent malic enzyme mitochondrialHuman Gene Id:
4200Human Swiss Prot No:
P23368Mouse Swiss Prot No:
Q99KE1Specificity:
ME2 Polyclonal Antibody detects endogenous levels of ME2 protein.Formulation:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.Concentration:
1 mg/mlStorage Stability:
-20°C/1 yearOther Name:
ME2; NAD-dependent malic enzyme; mitochondrial; NAD-ME; Malic enzyme 2MolecularWeight(Da):
65444Observed Band(KD):
65Function:
catalytic activity:(S)-malate + NAD(+) = pyruvate + CO(2) + NADH.,cofactor:Divalent metal cations. Prefers magnesium or manganese.,enzyme regulation:Subject to allosteric activation by fumarate.,miscellaneous:This isoenzyme can also use NADP(+) but is more effective with NAD(+).,similarity:Belongs to the malic enzymes family.,subunit:Homotetramer.,Subcellular Location:
mitochondrion,mitochondrial matrix,plasma membrane,membrane,intracellular membrane-bounded organelle,Expression:
B-cell,Placenta,Platelet,
- Western blot analysis of lysates from RAW264.7 and LOVO cells, using ME2 Antibody. The lane on the right is blocked with the synthesized peptide.
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