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MCM4 Polyclonal Antibody
Datasheet
Catalog Number:
E20-72681Amount:
100ulPrice:
225$Purification:
：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.Immunogen:
：The antiserum was produced against synthesized peptide derived from human MCM4. AA range:20-69Source:
：Polyclonal, RabbitGene Name:
：MCM4Dilution:
：Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.
- Immunohistochemistry analysis of paraffin-embedded human testis tissue, using MCM4 Antibody. The picture on the right is blocked with the synthesized peptide.
Background:
：minichromosome maintenance complex component 4(MCM4) Homo sapiens The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcriProtein Name:
：DNA replication licensing factor MCM4Human Gene Id:
：4173Human Swiss Prot No:
：P33991Mouse Gene Id:
：17217Mouse Swiss Prot No:
：P49717Specificity:
：MCM4 Polyclonal Antibody detects endogenous levels of MCM4 protein.Formulation:
：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.Concentration:
：1 mg/mlStorage Stability:
：-20°C/1 yearOther Name:
：MCM4; CDC21; DNA replication licensing factor MCM4; CDC21 homolog; P1-CDC21MolecularWeight(Da):
：96558Observed Band(KD):
：96Function:
：function:Involved in the control of DNA replication.,similarity:Belongs to the MCM family.,similarity:Contains 1 MCM domain.,Subcellular Location:
：nuclear chromosome, telomeric region,nucleus,nucleoplasm,membrane,MCM complex,Expression:
：Cervix,Epithelium,Testis,
- Western blot analysis of lysates from NIH/3T3 and K562 cells, using MCM4 Antibody. The lane on the right is blocked with the synthesized peptide.
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Catalog Number
- Amount:100ul
- Price:225$
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