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MC4-R Polyclonal Antibody
Datasheet
Catalog Number:
E20-72675Amount:
100ulPrice:
225$Purification:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.Immunogen:
The antiserum was produced against synthesized peptide derived from human MC4R. AA range:281-330Source:
Polyclonal, RabbitGene Name:
MC4RDilution:
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.
- Western blot analysis of lysates from MCF-7 cells, using MC4R Antibody. The lane on the right is blocked with the synthesized peptide.
Background:
melanocortin 4 receptor(MC4R) Homo sapiens The protein encoded by this gene is a membrane-bound receptor and member of the melanocortin receptor family. The encoded protein interacts with adrenocorticotropic and MSH hormones and is mediated by G proteins. This is an intronless gene. Defects in this gene are a cause of autosomal dominant obesity. [provided by RefSeq, Jan 2010],Protein Name:
Melanocortin receptor 4Human Gene Id:
4160Human Swiss Prot No:
P32245Mouse Gene Id:
17202Mouse Swiss Prot No:
P56450Rat Gene Id:
25635Rat Swiss Prot No:
P70596Specificity:
MC4-R Polyclonal Antibody detects endogenous levels of MC4-R protein.Formulation:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.Concentration:
1 mg/mlStorage Stability:
-20°C/1 yearOther Name:
MC4R; Melanocortin receptor 4; MC4-RMolecularWeight(Da):
36943Observed Band(KD):
37Function:
disease:Defects in MC4R are a cause of autosomal dominant obesity [MIM:601665].,function:Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. This receptor is mediated by G proteins that stimulate adenylate cyclase.,online information:Melanocortin receptor entry,similarity:Belongs to the G-protein coupled receptor 1 family.,subunit:Interacts with ATRNL1.,tissue specificity:Brain, placental, and gut tissues.,Subcellular Location:
nucleus,plasma membrane,integral component of membrane,Expression:
Brain,
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