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MC2-R Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-72674

  • Amount:

    100ul

  • Molecular Weight:

    33927 DaObserved Band:34 KD

  • Applications:

    WB;IHC-p;ELISA

  • Reactivity:

    Human;Mouse;

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human ACTHR. AA range:248-297

  • Source:

    Polyclonal, Rabbit,IgG

  • Western Blot analysis of various cells using MC2-R Polyclonal Antibody

  • Gene Name:

    MC2R

  • Dilution:

    WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000

  • Protein Name:

    Adrenocorticotropic hormone receptor

  • Human Gene Id:

    4158

  • Human Swiss Prot No:

    Q01718

  • Mouse Gene Id:

    17200

  • Mouse Swiss Prot No:

    Q64326

  • Specificity:

    MC2-R Polyclonal Antibody detects endogenous levels of MC2-R protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    MC2R; ACTHR; Adrenocorticotropic hormone receptor; ACTH receptor; ACTH-R; Adrenocorticotropin receptor; Melanocortin receptor 2; MC2-R

  • Background:

    melanocortin 2 receptor(MC2R) Homo sapiens MC2R encodes one member of the five-member G-protein associated melanocortin receptor family. Melanocortins (melanocyte-stimulating hormones and adrenocorticotropic hormone) are peptides derived from pro-opiomelanocortin (POMC). MC2R is selectively activated by adrenocorticotropic hormone, whereas the other four melanocortin receptors recognize a variety of melanocortin ligands. Mutations in MC2R can result in familial glucocorticoid deficiency. Alternate transcript variants have been found for this gene. [provided by RefSeq, May 2014],

  • Function:

    disease:Defects in MC2R are the cause of glucocorticoid deficiency type 1 (GCCD1) [MIM:202200]; also known as familial glucocorticoid deficiency type 1 (FGD1). GCCD1 is an autosomal recessive disorder due to congenital insensitivity or resistance to adrenocorticotropin (ACTH). It is characterized by progressive primary adrenal insufficiency, without mineralocorticoid deficiency.,function:Receptor for ACTH. This receptor is mediated by G proteins (G(s)) which activate adenylate cyclase.,similarity:Belongs to the G-protein coupled receptor 1 family.,subunit:Interacts with FALP/MRAP.,tissue specificity:Melanocytes and corticoadrenal tissue.,

  • Subcellular Location:

    Cell membrane; Multi-pass membrane protein.

  • Expression:

    Melanocytes and corticoadrenal tissue.

  • Immunofluorescence analysis of MCF7 cells, using ACTHR Antibody. The picture on the right is blocked with the synthesized peptide.

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