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MBD3 Polyclonal Antibody
Datasheet
Catalog Number:
E20-72671Amount:
100ulMolecular Weight:
32844 DaObserved Band:33 KDApplications:
WB;IHC-p;ELISAReactivity:
Human;Mouse;Purification:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.Immunogen:
The antiserum was produced against synthesized peptide derived from human MBD3. AA range:221-270Source:
Polyclonal, Rabbit,IgG
- Western Blot analysis of various cells using MBD3 Polyclonal Antibody
Gene Name:
MBD3Dilution:
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000Protein Name:
Methyl-CpG-binding domain protein 3Human Gene Id:
53615Human Swiss Prot No:
O95983Mouse Gene Id:
17192Mouse Swiss Prot No:
Q9Z2D8Specificity:
MBD3 Polyclonal Antibody detects endogenous levels of MBD3 protein.Formulation:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.Concentration:
1 mg/mlStorage Stability:
-20°C/1 yearOther Name:
MBD3; Methyl-CpG-binding domain protein 3; Methyl-CpG-binding protein MBD3Background:
methyl-CpG binding domain protein 3(MBD3) Homo sapiens DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. This gene belongs to a family of nuclear proteins which are characterized by the presence of a methyl-CpG binding domain (MBD). The encoded protein is a subunit of the NuRD, a multisubunit complex containing nucleosome remodeling and histone deacetylase activities. Unlike the other family members, the encoded protein is not capable of binding to methylated DNA. The protein mediates the association of metastasis-associated protein 2 with the core histone deacetylase complex. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013],Function:
function:Does not bind DNA by itself. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing.,similarity:Contains 1 MBD (methyl-CpG-binding) domain.,subcellular location:Nuclear, in discrete foci.,subunit:Heterodimer with MBD2. Part of the NuRD and the MeCP1 complex. Binds HDAC1, MTA2, DNMT1, p66-alpha and p66-beta.,Subcellular Location:
Nucleus. Chromosome. Nuclear, in discrete foci. Detected on chromatin, at promoter regions of active genes.Expression:
Brain,Cervix,Eye,Muscle,Uterus,
- Western blot analysis of lysates from Jurkat cells, using MBD3 Antibody. The lane on the right is blocked with the synthesized peptide.
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