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Cell Signal Transduction Research Antibodies
MaxiKα Polyclonal Antibody
Human;Mouse;Rat
WB;IHC-p;IF(paraffin section);ELISA
Polyclonal, Rabbit,IgG
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight137560 DaObserved Band:137 KD
Protein NameCalcium-activated potassium channel subunit alpha-1
Human Gene Id3778
Human Swiss Prot NoQ12791
Mouse Gene Id16531
Mouse Swiss Prot NoQ08460
Rat Gene Id83731
Rat Swiss Prot NoQ62976
SpecificityMaxiKα Polyclonal Antibody detects endogenous levels of MaxiKα protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameKCNMA1; KCNMA; SLO; Calcium-activated potassium channel subunit alpha-1; BK channel; BKCA alpha; Calcium-activated potassium channel; subfamily M subunit alpha-1; K(VCA)alpha; KCa1.1; Maxi K channel; MaxiK; Slo-alpha; Slo1; Slowpoke homolog
Functionalternative products:May be partially controlled by hormonal stress. Additional isoforms seem to exist,disease:Defects in KCNMA1 are the cause of generalized epilepsy and paroxysmal dyskinesia (GEPD) [MIM:609446]. Epilepsy is one of the most common and debilitating neurological disorders. Paroxysmal dyskinesias are neurological disorders characterized by sudden, unpredictable, disabling attacks of involuntary movement often requiring life-long treatment. The coexistence of epilepsy and paroxysmal dyskinesia in the same individual or family is an increasingly recognized phenomenon. Patients manifest absence seizures, generalized tonic-clonic seizures, paroxysmal nonkinesigenic dyskinesia, involuntary dystonic or choreiform movements. Onset is usually in childhood and patients may have seizures only, dyskinesia only, or both.,domain:The calcium bowl constitutes one of the Ca(2+) sensors an
Subcellular LocationCell membrane ; Multi-pass membrane protein .
ExpressionWidely expressed. Except in myocytes, it is almost ubiquitously expressed.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human MaxiKalpha. AA range:721-770
Gene NameKCNMA1
DilutionWestern Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.
Backgroundpotassium calcium-activated channel subfamily M alpha 1(KCNMA1) Homo sapiens MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit, which is the product of this gene, and the modulatory beta subunit. Intracellular calcium regulates the physical association between the alpha and beta subunits. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008],
Conjugated Antibody
This product is also available conjugated. Format: E20-72666-Conjugate. Price: $485 / Size: 100μl.
E20-72666-FITC$485 / 100μlE20-72666-Biotin$485 / 100μlE20-72666-HRP$485 / 100μlE20-72666-AP$485 / 100μlE20-72666-AF350$485 / 100μlE20-72666-AF405M$485 / 100μlE20-72666-AF488$485 / 100μlE20-72666-AF514$485 / 100μlE20-72666-AF532$485 / 100μlE20-72666-AF555$485 / 100μlE20-72666-AF568$485 / 100μlE20-72666-AF405S$485 / 100μlE20-72666-AF405L$485 / 100μlE20-72666-AF546$485 / 100μlE20-72666-AF594$485 / 100μlE20-72666-AF610$485 / 100μlE20-72666-AF635$485 / 100μlE20-72666-AF647$485 / 100μlE20-72666-AF680$485 / 100μlE20-72666-AF700$485 / 100μlE20-72666-AF750$485 / 100μlE20-72666-AF790$485 / 100μlE20-72666-APC$485 / 100μlE20-72666-PE$485 / 100μlE20-72666-Cy3$485 / 100μlE20-72666-Cy5$485 / 100μlE20-72666-Cy5.5$485 / 100μlE20-72666-Cy7$485 / 100μlE20-72666-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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