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Cell Signal Transduction Research Antibodies
Mat1 Polyclonal Antibody
Human;Mouse;Rat
WB;IHC-p;IF(paraffin section);ELISA
Polyclonal, Rabbit,IgG
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight35823 DaObserved Band:36 KD
Protein NameCDK-activating kinase assembly factor MAT1
Human Gene Id4331
Human Swiss Prot NoP51948
Mouse Gene Id17420
Mouse Swiss Prot NoP51949
SpecificityMat1 Polyclonal Antibody detects endogenous levels of Mat1 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameMNAT1; CAP35; MAT1; RNF66; CDK-activating kinase assembly factor MAT1; CDK7/cyclin-H assembly factor; Cyclin-G1-interacting protein; Menage a trois; RING finger protein 66; RING finger protein MAT1; p35; p36
Functionfunction:Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDC2/CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II.,similarity:Contains 1 RING-type zinc finger.,similarity:Contains 1 UIM (ubiquitin-interacting motif) repeat.,subunit:Associates primarily with CDK7 and cyclin H to form the CAK complex. CAK can further associate with the core-TFIIH to form the TFIIH basal transcription factor.,tissue specificity:Highest levels in colon and testis. Moderate le
Subcellular LocationNucleus.
ExpressionHighest levels in colon and testis. Moderate levels are present thymus, prostate, ovary, and small intestine. The lowest levels are found in spleen and leukocytes.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human MAT1. AA range:91-140
Gene NameMNAT1
DilutionWestern Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.
BackgroundMNAT1, CDK activating kinase assembly factor(MNAT1) Homo sapiens The protein encoded by this gene, along with cyclin H and CDK7, forms the CDK-activating kinase (CAK) enzymatic complex. This complex activates several cyclin-associated kinases and can also associate with TFIIH to activate transcription by RNA polymerase II. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011],
Conjugated Antibody
This product is also available conjugated. Format: E20-72662-Conjugate. Price: $485 / Size: 100μl.
E20-72662-FITC$485 / 100μlE20-72662-Biotin$485 / 100μlE20-72662-HRP$485 / 100μlE20-72662-AP$485 / 100μlE20-72662-AF350$485 / 100μlE20-72662-AF405M$485 / 100μlE20-72662-AF488$485 / 100μlE20-72662-AF514$485 / 100μlE20-72662-AF532$485 / 100μlE20-72662-AF555$485 / 100μlE20-72662-AF568$485 / 100μlE20-72662-AF405S$485 / 100μlE20-72662-AF405L$485 / 100μlE20-72662-AF546$485 / 100μlE20-72662-AF594$485 / 100μlE20-72662-AF610$485 / 100μlE20-72662-AF635$485 / 100μlE20-72662-AF647$485 / 100μlE20-72662-AF680$485 / 100μlE20-72662-AF700$485 / 100μlE20-72662-AF750$485 / 100μlE20-72662-AF790$485 / 100μlE20-72662-APC$485 / 100μlE20-72662-PE$485 / 100μlE20-72662-Cy3$485 / 100μlE20-72662-Cy5$485 / 100μlE20-72662-Cy5.5$485 / 100μlE20-72662-Cy7$485 / 100μlE20-72662-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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