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Cell Signal Transduction Research Antibodies
MASP-2 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight75733Da
Protein NameMannan-binding lectin serine protease 2
Human Gene Id10747
Human Swiss Prot NoO00187
Mouse Swiss Prot NoQ91WP0
SpecificityMASP-2 Polyclonal Antibody detects endogenous levels of MASP-2 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameMASP2; Mannan-binding lectin serine protease 2; MBL-associated serine protease 2; Mannose-binding protein-associated serine protease 2; MASP-2
Observed Band(KD)75
Functioncatalytic activity:Selective cleavage after Arg-223 in complement component C2 (-Ser-Leu-Gly-Arg-|-Lys-Ile-Gln-Ile) and after Arg-76 in complement component C4 (-Gly-Leu-Gln-Arg-|-Ala-Leu-Glu-Ile).,disease:Genetic variation in MASP2 is the cause of MASP2 deficiency [MIM:605102]. It is associated with susceptibility to infections and with the development of immunologic disease.,function:Serum protease that plays an important role in the activation of the complement system via mannose-binding lectin. After activation by auto-catalytic cleavage it cleaves C2 and C4, leading to their activation and to the formation of C3 convertase.,miscellaneous:Dimerization and MBL2 binding requires calcium ions.,online information:MASP2 mutation db,PTM:Activated by cleavage after Arg-444. The uncleaved zymogen is inactive towards synthetic substrates, but has sufficient activity to effect autocatalytic cl
Subcellular Locationextracellular region,extracellular exosome,
ExpressionLiver,Urine,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human MASP2. AA range:227-276
Gene NameMASP2
DilutionWestern Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
Backgroundmannan binding lectin serine peptidase 2(MASP2) Homo sapiens This gene encodes a member of the peptidase S1 family of serine proteases. The encoded preproprotein is proteolytically processed to generate A and B chains that heterodimerize to form the mature protease. This protease cleaves complement components C2 and C4 in order to generate C3 convertase in the lectin pathway of the complement system. The encoded protease also plays a role in the coagulation cascade through cleavage of prothrombin to form thrombin. Myocardial infarction and acute stroke patients exhibit reduced serum concentrations of the encoded protein. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016],
Conjugated Antibody
This product is also available conjugated. Format: E20-72656-Conjugate. Price: $485 / Size: 100μl.
E20-72656-FITC$485 / 100μlE20-72656-Biotin$485 / 100μlE20-72656-HRP$485 / 100μlE20-72656-AP$485 / 100μlE20-72656-AF350$485 / 100μlE20-72656-AF405M$485 / 100μlE20-72656-AF488$485 / 100μlE20-72656-AF514$485 / 100μlE20-72656-AF532$485 / 100μlE20-72656-AF555$485 / 100μlE20-72656-AF568$485 / 100μlE20-72656-AF405S$485 / 100μlE20-72656-AF405L$485 / 100μlE20-72656-AF546$485 / 100μlE20-72656-AF594$485 / 100μlE20-72656-AF610$485 / 100μlE20-72656-AF635$485 / 100μlE20-72656-AF647$485 / 100μlE20-72656-AF680$485 / 100μlE20-72656-AF700$485 / 100μlE20-72656-AF750$485 / 100μlE20-72656-AF790$485 / 100μlE20-72656-APC$485 / 100μlE20-72656-PE$485 / 100μlE20-72656-Cy3$485 / 100μlE20-72656-Cy5$485 / 100μlE20-72656-Cy5.5$485 / 100μlE20-72656-Cy7$485 / 100μlE20-72656-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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