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MARK2 Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-72652

  • Amount:

    100ul

  • Molecular Weight:

    87911(DA)

  • Price:

    225$

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human MARK2. AA range:562-611

  • Source:

    Polyclonal, Rabbit

  • Gene Name:

    MARK2

  • Dilution:

    Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.

  • Immunofluorescence analysis of HUVEC cells, using MARK2 Antibody. The picture on the right is blocked with the synthesized peptide.

  • Protein Name:

    Serine/threonine-protein kinase MARK2

  • Human Gene Id:

    2011

  • Human Swiss Prot No:

    Q7KZI7

  • Mouse Gene Id:

    13728

  • Mouse Swiss Prot No:

    Q05512

  • Rat Gene Id:

    60328

  • Rat Swiss Prot No:

    O08679

  • Specificity:

    MARK2 Polyclonal Antibody detects endogenous levels of MARK2 protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    MARK2; EMK1; Serine/threonine-protein kinase MARK2; ELKL motif kinase 1; EMK-1; MAP/microtubule affinity-regulating kinase 2; PAR1 homolog; PAR1 homolog b; Par-1b; Par1b

  • Background:

    microtubule affinity regulating kinase 2(MARK2) Homo sapiens This gene encodes a member of the Par-1 family of serine/threonine protein kinases. The protein is an important regulator of cell polarity in epithelial and neuronal cells, and also controls the stability of microtubules through phosphorylation and inactivation of several microtubule-associating proteins. The protein localizes to cell membranes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009],

  • Function:

    catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Activated by phosphorylation on Thr-208 by STK11 in complex with STE20-related adapter-alpha (STRAD alpha) pseudo kinase and CAB39.,function:Role in epithelial morphogenesis. Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. One or more isoforms may play a role in graft rejection.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. MARK subfamily.,similarity:Contains 1 KA1 (kinase-associated) domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 UBA doma

  • Subcellular Location:

    mitochondrion,actin filament,plasma membrane,cell-cell adherens junction,membrane,lateral plasma membrane,microtubule bundle,

  • Expression:

    Colon,Epithelium,Kidney,Placenta,Platelet,Tongue,

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Catalog Number

  • Amount:100ul
  • Price:225$

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MARK2 Polyclonal Antibody | EnoGene Biotech Co. Ltd