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Cell Signal Transduction Research Antibodies
MARK2 Polyclonal Antibody
Human;Mouse;Rat;Monkey
WB;IF/ICC;ELISA
Polyclonal, Rabbit,IgG
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight87911 DaObserved Band:85 KD
Protein NameSerine/threonine-protein kinase MARK2
Human Gene Id2011
Human Swiss Prot NoQ7KZI7
Mouse Gene Id13728
Mouse Swiss Prot NoQ05512
Rat Gene Id60328
Rat Swiss Prot NoO08679
SpecificityMARK2 Polyclonal Antibody detects endogenous levels of MARK2 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameMARK2; EMK1; Serine/threonine-protein kinase MARK2; ELKL motif kinase 1; EMK-1; MAP/microtubule affinity-regulating kinase 2; PAR1 homolog; PAR1 homolog b; Par-1b; Par1b
Functioncatalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Activated by phosphorylation on Thr-208 by STK11 in complex with STE20-related adapter-alpha (STRAD alpha) pseudo kinase and CAB39.,function:Role in epithelial morphogenesis. Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. One or more isoforms may play a role in graft rejection.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. MARK subfamily.,similarity:Contains 1 KA1 (kinase-associated) domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 UBA doma
Subcellular LocationCell membrane; Peripheral membrane protein. Cytoplasm. Lateral cell membrane. Cytoplasm, cytoskeleton. Cell projection, dendrite . Cytoplasm . Phosphorylation at Thr-596 by PRKCZ/aPKC and subsequent interaction with 14-3-3 protein YWHAZ promotes relocation from the cell membrane to the cytoplasm.
ExpressionHigh levels of expression in heart, brain, skeletal muscle and pancreas, lower levels observed in lung, liver and kidney..
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human MARK2. AA range:10-59
Gene NameMARK2
DilutionWestern Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Backgroundmicrotubule affinity regulating kinase 2(MARK2) Homo sapiens This gene encodes a member of the Par-1 family of serine/threonine protein kinases. The protein is an important regulator of cell polarity in epithelial and neuronal cells, and also controls the stability of microtubules through phosphorylation and inactivation of several microtubule-associating proteins. The protein localizes to cell membranes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009],
Conjugated Antibody
This product is also available conjugated. Format: E20-72651-Conjugate. Price: $485 / Size: 100μl.
E20-72651-FITC$485 / 100μlE20-72651-Biotin$485 / 100μlE20-72651-HRP$485 / 100μlE20-72651-AP$485 / 100μlE20-72651-AF350$485 / 100μlE20-72651-AF405M$485 / 100μlE20-72651-AF488$485 / 100μlE20-72651-AF514$485 / 100μlE20-72651-AF532$485 / 100μlE20-72651-AF555$485 / 100μlE20-72651-AF568$485 / 100μlE20-72651-AF405S$485 / 100μlE20-72651-AF405L$485 / 100μlE20-72651-AF546$485 / 100μlE20-72651-AF594$485 / 100μlE20-72651-AF610$485 / 100μlE20-72651-AF635$485 / 100μlE20-72651-AF647$485 / 100μlE20-72651-AF680$485 / 100μlE20-72651-AF700$485 / 100μlE20-72651-AF750$485 / 100μlE20-72651-AF790$485 / 100μlE20-72651-APC$485 / 100μlE20-72651-PE$485 / 100μlE20-72651-Cy3$485 / 100μlE20-72651-Cy5$485 / 100μlE20-72651-Cy5.5$485 / 100μlE20-72651-Cy7$485 / 100μlE20-72651-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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